The Global Diabetes Community Forum
Januvia is a diabetes drug that works by increasing the levels of GLP-1, an incretin hormone that stimulates insulin secretion. Another diabetes drug, Byetta, is an artificial, injected, form of GLP-1. Januvia is quite different. It is a pill that causes the GLP-1 your body secretes on its own to rise to a higher than normal level by inhibiting the action of DPP-4. DPP-4 is an enzyme (a.k.a. protease) which when it is left to its own devices, chops up GLP-1 and another hormone, GIP. When DPP-4 is inhibited, GLP-1 does not get chopped up and remains active in the body. When GLP-1 is active, it stimulates insulin secretion when blood sugars rise.
BaliRob wrote:Swimmer thanks for your post - but you may not have kidney problems??
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