liraglutide is more effective....suggest NN study

[Cowboyjim]

http://www.novonordisk.com/press/sea/sea.asp?sNewsTypeGUID=&lMonth=&lYear=&sLanguageCode=&sSearchText=&fb=1218&cat=pr&sShowNewsItemGUID=3eeb78dc-6fc4-4fb6-aa0a-01c71dda7096&sShowLanguageCode=en-GB

News from Novo - some serious actual science for a change maybe? NN is really pushing the boat out on this one...

This new study retrospectively analysed clinical trial data, which included 1,530 patients with type 2 diabetes, using recursive partitioning analyses to identify factors that predict greatest therapeutic benefit in response to treatment with liraglutide. Responders in the study were defined as those patients achieving a composite endpoint of HbA1c<7% with no weight gain and no hypoglycaemia over 26 weeks.

Key findings from the study include:
Overall 34% of individuals treated with liraglutide 1.8 mg achieved the prespecified composite endpoint in the retrospective analysis.

More patients with HbA1c<8.5% at the start of the study reached the composite endpoint, compared to patients with HbA1c=8.5%, 46% vs19% responders, respectively (p<0.0001).

More patients with HbA1c<8.5% at the start of the study and who had previously received treatment with a single antidiabetic medicine or diet modification reached the composite endpoint, compared to those who had received combination therapy (56% vs 36% responders, respectively, p<0.0001).

In another subgroup of female patients, more patients with HbA1c<8.5% at the start of the study, previous treatment with a single antidiabetic medicine or diet modification and a shorter duration of diabetes (<4.9 years) reached the composite endpoint, compared to patients with a longer duration of diabetes (=4.9 years), 74% vs 49% responders, respectively (p=0.013).



http://en.wikipedia.org/wiki/Liraglutide

[Hobs]

As one who hurls the Victoza lance into his abdomen each morning at 8am, I am pleased to read the above; but it is of course, addressing the already converted
I have been injecting since my surgery wanted a 'victim' to try it on and ever since we have both been very pleased with the results
2+ yrs later and it is still doing what I need it to and long may it do so

[sky]

sad to say---for a little over a year i used victoza it was excellent-doctor was amazed readings were in normal ranges-we were all very excited--then after all that time with no changes to my routine my readings started creeping up again, then after some time there were no real benefits from using liraglutide/victoza no one understood why but it just stopped being effective-needless to say it was very frustrating & as i tried earlier to go on insulin, on recommendation i then pushed for insulin as i wanted to stop jerking around with meds that didn't really have a lasting effect, more poor cells needed a break--on lantus 60units for about a month now and hoping finally to get normalized & also considering the newcastle diet lo cal.. will see--so i am reporting here that victoza was after all a big disappointment (for me that is) in the end.

[Cowboyjim]

Interesting and entirely different postings... just goes to show that we iz all individuals and a one-size-fits-all approach is not the solution.

Studies must use a good size sample to be valid which obviously increases the cost and time. But within the usual bell-curve spread there will cases like this I am afraid. It is how well it performs for the average, whoever that is, that will give the yay or nay.

Best wishes to you both!