Recent Content by SimonCrox

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    Bydureon and sickness

    Hi, I'm sorry that you are having such a rough time with the Bydureon. This is a recognised side effect of this class of drugs, and is a pity because this class has useful benefits. Bydureon (long acting exenatide) is less likely to cause vomiting than semaglutide:-...
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    Thrush

    Hi, As others have said, good glucose control is helpful. And fluconazole tablets get the anti-fungal medication where it needs to be, unlike antifungal creams, but there is an interaction between fluconazole and statins so ask GP if you should omit the statin whilst on the fluconazole tablets...
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    does anyone inject dulaglutide (trulicity)

    I have been told by the makerss of Liraglutide that taking these agents on an empty stomach ie first thing in morning, avoids the nausea problem, I would like to know what other people here think of this claim. I have seen late nausea occur with liraglutide for no other appaent reason; I guess...
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    Pregabalin for Nerve Pain

    Hi, The swollen ankles is well described in the SPC of pregabalin, although not well recognised by medical staff. I have used some tapentadol in an elderly person who was intolerant of other opiates, but the tapentadol suited him well; not all GPs are happy to prescribe tapentadol. I would get...
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    Lantus to tresiba

    Hi Are you sure that it is the tresiba? Do you think that you could be going hypo overnight? That could make you tired during day. On the other hand, if your glucose levels were too high, that could also make you tired. There are many causes of tiredness so it might be worth seeing your...
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    Low Blood Pressure

    Hi, great news about the improved glucose levels. Do you take blood pressure tablets, and have you lost weight? Each Kg of weight is worth about 1 mmHg systolic BP so if you lose 10 Kg, your BP if on BP tablets may drop 10 mm Hg. I guess that you have checked that you are not going hypo? Not an...
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    Thrush

    Hi, I agree with the folk above that if your glucose levels are controlled, it is unlikely to be the Tresiba. Tresiba is new but it has been in use for 5 years now (I think), and it is mainly human insulin with a side chain added to make it slow release. So no reason to believe would cause...
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    Complications - time to develop

    I concur with @ringi above. In a way, it is affected by whether one has type 1 diabetes when one is diagnosed soon after onset in which case specific DM complications are almost unknown before 5 years of disease, or whether one has Type 2 DM when there may be a 10 year delay indiagnosis, and...
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    Semaglutide

    The LEADER Trial of Liraglutide ( https://www.nejm.org/doi/full/10.1056/NEJMoa1603827 ) showed a reduction in nephropathy but a slight, non-significant increase in retinopathy; it also showed a reduction in any death, heart attack and stroke which was significant and far greater than the extra...
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    Semaglutide

    The retinopathy was often persistent and thought to need treatment:- Diabetic retinopathy complications occurred in 50 patients (3.0%) in the semaglutide group and 29 (1.8%) in the placebo group (hazard ratio, 1.76; 95% CI, 1.11 to 2.78; P=0.02) (Table 2, and Table S9 and Fig. S5 in the...
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    Semaglutide

    Semaglutide is really interesting because in SUSTAIN 6 it reduced adverse cardiovascualr outcomes:- https://www.nejm.org/doi/full/10.1056/NEJMoa1607141 This is of crucial importance since diabetic folk are at increased risk of heart attack and stroke. Interestingly, semaglutide can be given...
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    Why am I diabetic 2?

    As above, you need to see your GP and ask what is the evidence for diabetes. We screened the elderly of Melton Mowbray for diabetes 30 years ago and on the GP diabetes register were three folk who did not have diabetes; one had impaired glucose tolerance, one had a low renal threshold for...
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    does anyone inject dulaglutide (trulicity)

    It has just been shown that dulaglutide reduces the risk of heart attack and stroke, so really useful if one can tolerate it. https://investor.lilly.com/news-releases/news-release-details/trulicityr-dulaglutide-significantly-reduced-major Best wishes
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    Glidipion

    The active job probably contributes to the low weight, but an HBA1c of 124 new units is pretty high; when does he next see the doctor? I'd be surprised if one oral agent controlled his glucose levels if already on diet and exercise How long has he had the diabetes? Sorry, this is not...
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    Glidipion

    Hi As others have said, this is pioglitazone 15 mg ie low dose In PROACTIVE trial, this decreased the rate of heart attack and stroke in folk who had previously had these. It probably decreases the incidence of dementia, and probably improves fatty liver. It does not cause hypoglycaemia and can...