How dietary fat can influence the brain in weight loss.

[ickihun]

I saw this and thought a few people might like to read this.
@bulkbiker and @Brunneria maybe?
I wasn't sure if this section of the forum or discussions?

http://www.bariatricnews.net/?q=news/112756/immune-cells-brain-may-drive-overeating-and-weight-gain

 

[Brunneria]

Thanks @ickihun

The thing that jumped out when I read the link was this paragraph:
In this study, the researchers fed mice a fast food-like diet rich in fat for four weeks, which is known to cause microglia to expand in number and to trigger local inflammation within the MBH. Mice fed such a diet also eat more food, burn fewer calories, and gain more weight compared to mice eating a more healthy, low-fat diet.

It highlights quite a few things to me
- the researchers were testing mice, not humans
- the mice were fed 'a fast food-like diet rich in fat for 4 weeks' and we all know that fast food is rich in carbs AND fat, don't we? Yet from that point on in the article, the diet is constantly referred to as 'rich in fat', not rich in 'carbs and fat'.
- there was a strong assumption that eating a low-fat diet is healthy

There is a lot there that I disagree with, but I don't know whether that is because the research was set up badly, or the person who wrote the article did so without understanding what they were saying, but from what I have just read I wouldn't compare my human body's reactions on a ketogenic diet to a lab mouse's reactions on a high fat, high carb 'fast food-like' diet. It is like comparing chalk and cheese. Or Stork margarine and organic grass fed butter. Or comparing Pop Tarts with home made low carb muffins, fresh homegrown strawberries and organic clotted cream...

 

[bulkbiker]

The opening sentence really p**ses me off.. it makes a bold statement the semi qualifies it and as @Brunneria says if you read on further down you realised how flawed a study it is. Just really bad science.
reminds me of this...

 

[Guzzler]

That point caught my immediate attention, too. A fast food diet.

Wouldn't it be better to have people eat a proper healthy diet than develope a drug to treat people whose diet is carb rich?
Overall though, a really interesting article. Thank you for the link.

 

[Art Of Flowers]

I just watched the documentary by Michael Mosely on how the digestive system works. Apparently it has its own brain to organise how we digest food. One section of the film talks about how bypass surgery impacts messages to the brain telling us we are full and this is why the surgery leads to weight loss.
See http://www.bbc.co.uk/iplayer/episod...us-world-of-the-human-stomach?suggid=b01kpt6c

 

[ickihun]

Thanks @ickihun

The thing that jumped out when I read the link was this paragraph:
In this study, the researchers fed mice a fast food-like diet rich in fat for four weeks, which is known to cause microglia to expand in number and to trigger local inflammation within the MBH. Mice fed such a diet also eat more food, burn fewer calories, and gain more weight compared to mice eating a more healthy, low-fat diet.

It highlights quite a few things to me
- the researchers were testing mice, not humans
- the mice were fed 'a fast food-like diet rich in fat for 4 weeks' and we all know that fast food is rich in carbs AND fat, don't we? Yet from that point on in the article, the diet is constantly referred to as 'rich in fat', not rich in 'carbs and fat'.
- there was a strong assumption that eating a low-fat diet is healthy

There is a lot there that I disagree with, but I don't know whether that is because the research was set up badly, or the person who wrote the article did so without understanding what they were saying, but from what I have just read I wouldn't compare my human body's reactions on a ketogenic diet to a lab mouse's reactions on a high fat, high carb 'fast food-like' diet. It is like comparing chalk and cheese. Or Stork margarine and organic grass fed butter. Or comparing Pop Tarts with home made low carb muffins, fresh homegrown strawberries and organic clotted cream...

That's what I noticed to be the most controversial part too.
I think they really mean carbs rather than fat, too?

 

[Robbity]

I skimmed through, saw the bit about wee mousies being fed a fast food diet rich in fats - and thought "You can not be serious!" and gave up on it....

Robbity

 

[covknit]

I just watched the documentary by Michael Mosely on how the digestive system works. Apparently it has its own brain to organise how we digest food. One section of the film talks about how bypass surgery impacts messages to the brain telling us we are full and this is why the surgery leads to weight loss.
See http://www.bbc.co.uk/iplayer/episod...us-world-of-the-human-stomach?suggid=b01kpt6c

I believe that the surgery cits off the part of the stomach where ghrelin is produced. They are the hormones that tell us we are hungry. Switch them off and our desire for food is reduced.

 

[Guzzler]

I just watched the documentary by Michael Mosely on how the digestive system works. Apparently it has its own brain to organise how we digest food. One section of the film talks about how bypass surgery impacts messages to the brain telling us we are full and this is why the surgery leads to weight loss.
See http://www.bbc.co.uk/iplayer/episod...us-world-of-the-human-stomach?suggid=b01kpt6c

@Art Of Flowers
Aye, the brain in the human gut is of equal size to that of a cat, it was a really interesting documentary and the book on gut health is excellent.

 

[ringi]

It is well known.

Reduce fat while eating lots of carbs: -> small benifit
Greatly reduce card regardless of how much fat we eat: very very good
​

They have just confirmed what we already know that "less fat with your fast food reduces the risk of the fast food a little", but it say nothing about eating the fast food (high carb) in the first place.

 

[Resurgam]

Well - what folks don't want to see - a hundred years before Atkins there was William Banting - he self published his 'Letter on corpulence' at about cost to try to get across the low carb message.
There have been numerous trials of various diets done, but the low carb option has never been taken at face value, there have always been assumptions made before setting up the details, or the results have been carefully doctored.

 

[Indy51]

Some good reasons to distrust mouse studies, especially with diabetes drugs:

https://futurism.com/now-know-why-diabetes-treatments-work-mice-not-people/

 

[ickihun]

I believe that the surgery cits off the part of the stomach where ghrelin is produced. They are the hormones that tell us we are hungry. Switch them off and our desire for food is reduced.

But some patients gain that hunger back and cheat with high carb food which then causes cravings so overwelming they risk splitting the staples in their egg size stomach. Gulp!!!
Very dangerous.

 

[covknit]

But some patients gain that hunger back and cheat with high carb food which then causes cravings so overwelming they risk splitting the staples in their egg size stomach. Gulp!!!
Very dangerous.

OMG that makes me wanna double up with sympathy pains. Carbs are evil and having gonethrough all the pain leading up and through surgery it does make me wonder why people do it to themselves