LADA

[mishigato]

Hi there,

I was first diagnosed as T1 10 months ago with a HbAc1 14. Female, 35 y/o, fit. I was put on Lantus and Humalog from day one ( Lantus 12, Humalog 4-4-4), slowing down the dosses to Lantus 6 Humalog 1-2-2/ 0-0-1/2 (if exercise for 30 minutes in the morning). My present HbAc1 is 6.3. After these change, and into 6 months of diagnoses, my nurse decided to make some tests as my honeymoon period seems too long too sweet.

Three days ago I have been told I am negative for antibodies ( which runs me out of Type1), but my C-peptides are pretty low ( 340 ) which runs me out of type2.

I have been told I am LADA. ( even after researching I think I don't tick all the bozes...)

From monday I will keep my Lantus- 6, will be off Humalog and starting on gliclazide ( 1 pill a day to start with)

Does this all sound right to you? Do you have any information that could help me?

Thank you so much. I am pretty new to all this, making gigantic efforts to change my lifestyle and remaining positive about this all.

Some info about LADA, or a tyoe of 1.5 diabetes.

http://asweetlife.org/a-sweet-life-staff/featured/what-is-lada/5999/

 

[AMBrennan]

Sorry to add to the confusion, but I'd have thought that negative antibodies would rule out* LADA (latent *autoimmune* diabetes in adults)?

* well, indicate that it's probably T2

 

[phoenix]

Hi,
No answer just a few comments
1)LADA is by it's definition autoimmune,

2) There is an offcial diagnosis for people with T1 and no markers for antibodies: T1b, (idiopathic) . The most reported form of this is found in people of African and Indian origin and in this case it has a very specific form (insulin dependence actually comes and goes)
http://www.diabetestypes.org/type-1-dia ... abetes.htm
This may not be the only form of T1b (just one that has been identified)

3) Reading on forums though there seem to be quite a few people who have all the appearances of T1 (ketosis prone, insulin sensitive) but no antibodies. One lady on another forum has called herself type weird!

4) When children are diagnosed with T1 they are rarely tested for antibodies, so we don't know how many childhood onset T1s would test negative for the markers of autoimmunity. One very recent piece of reseach on children found that out of 900 newly diagnosed T1 children tested within 2 weeks of diagnosis 145 (16.1%) were negative for all five anti-islet autoantibodies, and autoantibody negativity significantly increased with age http://www.ncbi.nlm.nih.gov/pubmed/21138544

5) In 2007 a 'new' autoantibody for T1 was reported: ZnT8a. Interestingly it was detected in up to 80% of patients with new-onset T1D and 26% of patients with T1D otherwise classified as negative on the basis of existing markers. http://www.ncbi.nlm.nih.gov/pubmed/17942684 (really difficult paper for us non specialists!) I don't think that testing for this is available, or indeed whether subsequent research has backed up the original findings.

6) There is always the possibility of MODY which is not T1, is genetic and will often respond well to oral medications.

Hope all this isn't too confusing, but there aren't any simple answers!

edit; missed out a figure

 

[anna29]

Thanks for this info phoenix, I have found it very useful and have stored it away for future reference!
Only because last time I saw my consultant diabotologist/endiocrinologist he wanted to give me 6 months on levemir insulin cranking up the levels weekly till it kicked in and brought some control of my errattic BG levels.
If not he mentioned testing me for slow onset in the new year.
Up to now am still yo-yo 'ing with high then medium then high levels again, despite eating so little and on decent chunks of insulin .
Have spent the last 6months "baffled" as I am doing what have been told to do and no positive results yet!
Anna.

 

[mishigato]

Thanks for answer, I actually kind of understand it...

I am going on friday to nurse, will bring out theses questions...

I put the thread on the first place because being negative atibodies but diagnosed as LADA...which doesn't make sense to me now after doing some shallow research about Lada on the net.

Thanks Phoenix, I will ask to my endo about T1b...

Thank you very much.