Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes

December 05, 2011

Christopher T. Brown et al. PLoS ONE. doi:10.1371/journal.pone.0025792

Recent studies have suggested a bacterial role in the development of autoimmune disorders including type 1 diabetes.

Data presented by the authors, and also published elsewhere suggest that microbial-induced butyrate production, and subsequent mucin synthesis, with a corresponding enhancement of tight junctions may contribute to the development of autoimmunity for type 1 diabetes in humans.

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