A new study carried out at Washington University School of Medicine in St. Louis has identified a key regulator of insulin sensitivity that could play a part in the development of obesity and diabetes, as well as the ageing process. It is hoped the discovery will lead to new treatments for patients suffering from type 2 diabetes and other health issues that arise from an inability to control blood sugar levels.
The research, which was published in the journal PLoS One, showed that the protein, called TBC1D3, is able to maintain the insulin pathway open so that the cells still take up glucose. It was also found that greater amounts of TBC1D3 impede a feedback loop that usually deactivates the insulin signal into the cell from receptors present on the membrane of the cell.
Senior author, Philip Stahl, commented "When cells made more of the TBC1D3 protein, they had a much bigger response to insulin ."
He added "We found that TBC1D3 significantly slows the deactivation of a molecule that relays signals from the insulin receptor. This enhances the cells� response to insulin."
TBC1D3 is one of the most duplicated genes in the human body, present up to 50 times in our DNA, and the scientists are exploring what factors regulate the activity of the gene.
Protein identified that could be responsible for obesity and diabetes
Wed, 15 Feb 2012
Your comments may be moderated. Please report any spam, illegal, offensive or libellous posts.
Also related to this storyDiabetes Products
Diabetes Online Community
Type 2 Diabetes
Blood Sugar Levels
Low Carb Diet
Diabetes in India
Vascular Health Checks
Breast-feeding can help to reduce childhood obesity for diabetic mothers
Obesity drug claimed to help people lose weight without exercise
Rise in obesity levels in primary school children raises diabetes concerns
Call for obesity levels of South Asians to be re-assessed
Obesity increasing in Scotland could impact on level of diabetes
Moving to a better area can reduce risk of obesity, says study
Dancing can help reduce obesity and risk of diabetes
Obesity results from dysfunction of fat cells, says study
Increase in obesity to blame for big rise in diabetic mortality rate
More realistic measure of obesity needed, says study
Obesity device can also help control diabetes, says study
Obesity surgery case fails at the Court of Appeal
Another study finds diabetes and obesity in pregnancy increases risks
Master regulator gene found to be responsible for obesity and diabetes, says study
Metformin trialled as anti-obesity drug for unborn babies
Supermarket food lessons to combat obesity and diabetes
Plan for more obesity research to help diabetes problem
Mothers with diabetes that breast-feed could lower obesity in babies
Obesity doubles in 30 years as world BMI average grows