Dompe, one of Italy's leading biopharmaceutical companies, has begun late-stage testing of a novel compound called reparixin as a potential new treatment for patients with type 1 diabetes.
The selective chemokine interleukin-8 inhibitor has been advanced into a Phase III trial after previous studies showed it can improve the efficacy and safety of transplantation of pancreatic islet cells in type 1 diabetics .
Described by Dompe as "the new frontier in type 1 diabetes", islet transplantation is an experimental procedure that involves taking isolated islet cells - clusters of cells in the pancreas that include insulin-producing beta cells - from a donor pancreas and transferring them into another person to enable the production and release of insulin, which is required for regulating blood glucose levels.
"The idea that a targeted anti-inflammatory treatment could help pancreatic islet transplantation become a standard procedure has been confirmed in earlier clinical trials on this investigational drug," said principal investigator, Lorenzo Piemonti of the San Raffaele Hospital in Milan.
"Our hope and goal is to see significant improvement of patient's quality of life and lower immune suppression-related risk."
The Phase III trial will involve a total of 60 patients and will be conducted in 10 centres across Europe and America.
Dompe chief executive, Eugenio Aringhieri, said the beginning of the late-stage study "marks a key milestone" for the Milan-based firm, adding that global cases of type 1 diabetes are on the rise, causing a significant impact on "the young population".
Investigational type 1 diabetes drug reaches Phase III trial
Thu, 01 Nov 2012
Your comments may be moderated. Please report any spam, illegal, offensive or libellous posts.
Also related to this storyThe link between strokes and diabetes
Join the diabetes online community
Type 1 diabetes explained
Symptoms of type 1 diabetes
About insulin jabs
Insulin pumps guide
Islet cell transplants
Drug treatments for diabetes
Diabetes and sex
Diabetes and pregnancy
Diabetic products online
Diabetes tools and calculators
Prevention of diabetes mellitus
Insulin information guides
About type 2 diabetes
Blood sugar levels guide
Available diabetes treatment
Diabetes drug may have potential to treat Alzheimers
Zealand Pharma begins clinical development of type 2 diabetes drug
Clopidogrel drug may be less beneficial for diabetic patients after MI
Overdose drug shows heart potential for type 2 diabetes patients
FDA approves generic versions of diabetes drug Actos
Use of Tradjenta diabetes drug expended in the US
More than 40m diabetes drugs prescribed in 2011/12
Type 2 diabetes drugs raise bladder cancer risk
Diabetes drugs deliver strong results for Novo Nordisk
Jentadueto combination diabetes drug gets European approval
Lucentis drug can treat diabetes-related vision loss
Aurobindo diabetes drug approved by US health regulator
Janssen to assist development of regenerative diabetes drugs
Metformin diabetes drug could mend injured brains
Diabetes drug Actos associated with bladder cancer once more