Scientists in America have identified a new biomarker for risk of type 2 diabetes.
Research conducted by Thomas J. Wang, director of the Division of Cardiology at the Vanderbilt Heart and Vascular Institute, and Robert Gerszten and colleagues at Massachusetts General Hospital found the metabolite 2-aminoadipic acid (2-AAA) can help predict type 2 diabetes risk up to 12 years before its onset.
The study was based on human sampling from the Framingham Heart Study that tracked potentially diabetic people and those that had no potential for type 2 diabetes for 12 years.
During this period, they found that individuals who had higher 2-AAA concentrations were up to four times more likely to develop type 2 diabetes compared with people with lower levels.
The scientists also conducted laboratory studies which showed that giving 2-AAA to mice alters the way they metabolise glucose. The molecules appear to influence the function of the pancreas, which is responsible for producing the blood sugar-regulating hormone insulin.
"2-AAA appears to be more than a passive marker. It actually seems to play a role in glucose metabolism," Wang said.
"It is still a bit early to understand the biological implications of that role, but these experimental data are intriguing in that this molecule could be contributing in some manner to the development of the disease itself."
The findings are published in the latest issue of the Journal of Clinical Investigation.
Novel biomarker for type 2 diabetes risk identified
Tue, 17 Sep 2013
Your comments may be moderated. Please report any spam, illegal, offensive or libellous posts.
Also related to this storyWhat is pre-diabetes
Type 2 diabetes risk factors
Type 2 diabetes symptoms
Diabetes and metabolism
Diabetes screening tests
Type 2 diabetes an independent risk factor for heart disease in younger women
Blueberries and whole fruit may decrease type 2 diabetes risk but fruit juice increase it
Genetic factor associated with increased risk of heart disease in Type 2 diabetes
Use of antipsychotic drugs in children dramatically increases type 2 diabetes risk
Walking to work can lower type 2 diabetes risk
Cutting fatty liver slashes type 2 diabetes risk