People who have type 2 diabetes and prior cardiovascular disease are more at risk of developing chronic kidney disease, according to new research.
The LEADER trial compared people with type 2 diabetes and a high cardiovascular (CV) risk to those who have never had those health problems and discovered those without were at less risk. More than 400 centres in 32 countries took part.
Speaking to Endocrine Today, Ilhan Satma, who is the managing director of endocrinology and metabolic diseases at Istanbul University, said: “We identified advanced age, long diabetes duration, poor glycemic control, comorbidities and medications used as factors significantly associated with CKD at baseline in the LEADER trial population with established CVD.”
The data showed that 51.9 per cent of the participating people with previous cardiovascular problems had chronic kidney disease (CKD).
The highest rates were in Asia with 75.8 per cent, followed by 43.4 per cent in the Middle East and 43.7 per cent in Europe.
Increased age, HbA1c, length of type 2 duration, systolic blood pressure and triglyceride levels, and a greater number of antihypertensive medications were also associated with a higher risk of CKD.
Researchers said those who had increased diastolic blood pressure, no diuretic therapy, angina or stroke were less likely to have CKD.
Satman added: “Based on our results, we strongly recommend early screening and inclusion of high CV risk patients with type 2 diabetes into CKD prevention programs.”
The LEADER trial was funded by Novo Nordisk.
