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I seem to have a problem, and wonder if anyone else has experienced this. My job is office based and relatively stationary, at least in comparison to my weekend activity when I am exercising moderately. During the week I have to take much more insulin and inject 30 minutes prior to lunch to prevent high post meal BGs. Then at weekends I tend to hypo often and need to reduce my insulin and inject just before or during my meals. I guess to some extent this is expected, however in my case it just seems to be really exaggerated. I am starting to wonder if there is some sort of resistance to insulin, or difficulty in absorption. Achieving reasonable results during the week has become difficult. Any advice or help is much appreciated. I am 40 years old, taking humalog and lantus and have been diabetic for over 27 years.