I am 71 and had been on Metformin for many years. During that time my appetite was never very good, mainly I suppose because Metformin is an appetite suppressant and aimed at overweight people. I have never been overweight, my present weight of 60kg, being my nine month pregnant weight, is the highest I've ever been. Last year I felt very tired and my appetite was even worse than usual, I had blood tests done and found that my B12 was low. Metformin is well known for causing B12 deficiency. After a course of injections my appetite got a bit better but the thing that really helped was when I decided to stop taking them for a week or so to see what happened. It was miraculous, my appetite got better straight away, I even had hunger pains, something I hadn't experienced for years. My guilt made me start taking them again for a few months but last week, when I saw my diabetes nurse for my annual review I told her I had been naughty and had stopped taking them and she asked me how I was. I told her my appetite was better and I felt better in myself, except for the fact that I've had a cough for the last five weeks. Anyway, she told me to stop taking them and took them off the prescription. My sugar levels are mostly below 10 but for some reason they shoot up before bed, possibly caused by me snacking in the evening or my Lantus wearing off so I think that needs tweaking a bit. I don't want to have to go back on Metformin as I didn't think it had done me much good and was actually doing me harm with the B12 deficiency. I would just stop taking them and test regularly and see what happens.