Interesting comments above re low glucose levels in T2DM; totally concur with the comments about insulin. But sulphonylurea tablets such as gliclazide, glipizide, glibenclamide, glimepiride and tolbutamide can also make the glucose levels go too low. In the UKPDS study, sulphonylureas were just as likely to cause hypos as insulin. In Asplund's work from Sweden, one could kill an elderly Swede with just 2.5 mg glibenclamide (thankfully very rare). So, we are much more careful with these drugs now (don't all go and stop them), but one can have a devastating hypo in an older person with sulphonylureas quite easily. Don't mean to be scary, but want folk to be safe, and we have far more options now.
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