From
https://www.livescience.com/62689-otzi-iceman-mummy-heart-disease.html
Given that Ötzi wasn't overweight, didn't smoke tobacco, regularly exercised and likely didn't have a high-fat diet (at least by today's standards), it appears that his genes — and not his daily routine — explained his health condition.
"I suspect that lifestyle didn't play a major role in his development of plaque," Dr. Philip Green, an interventional cardiologist at New York-Presbyterian who wasn't involved with the study, told Live Science. Despite the suggestion that Ötzi go vegetarian, Zink sees it another way. "Compared to modern standards, he would not be considered as a risk patient," Zink told Live Science. "So, I think a different diet, such as vegetarian or vegan, wouldn’t have helped Ötzi."
There is no doubt Ötzi is one of the oldest cases of vascular calcification, and "a medical example showing that a genetic predisposition is probably the most important trigger factor for arteriosclerosis and coronary heart disease," study co-researcher Patrizia Pernter, a radiologist at Bozen-Bolzano, said in a statement.