According to Frio wrbsite
"FRÍO
keeps in-use insulin and 29 other temperature sensitive medicines cool and safe, within safe temperatures of 18-26°C (64.4-78.8°F) for a minimum of 45 hours, even in a constant environmental temperature of 37.8°C (100°F)."
In my opinion avoid the overpriced Frio.
Notice from their website it says keeps at a safe temperature but it doesn't say it keeps it at an effective temperature. Insulin is best kept and most effective at 2°C-8°C (look at the back of your insulin pen box).
I found in warm temps eg 26°C-28°C it takes longer to work from taking it out of the Frio and/or I have had to inject more insulin as a result than I would have had to with insulin from the fridge.
I took a Frio Duo to Spain where it was sometimes in the 30s after reading "the hype" and found my insulin wasn't working as it should even after following their instructions to the letter prior to use as the Frio doesnt cool the pen anywhere near to 2°C - 8°°C (it just cools to a few degrees below the ambient temperature according to them ) so the insulin takes longer to work if at all.
I had to buy a small thermos flask when in Spain and it worked flawlessly as if you had just removed the insulin from the fridge.
Put the thermos flask in the freezer overnight or fridge. Next day remove it and put your insulin pens in. Pens wont freeze as you're not storing them in the freezer.
Keeps pens much cooler than Frio which even on their own website even says the Frio will only to cool pens a few degrees below ambient temperature.
With the flask it cools far better and is cheaper., your then cool insulin works as it would at home from the fridge.
If ever I'm away from home I store my insulin in the small thermos flask and never have any problems so I know it's going to work as it would at homefrom the fridge