I have to say though, enjoyed above, all, but there is something of merit from carbsanity - Evelyn has written extensively and well about the role of free fatty acids in metabolic disorders, to the extent that I have included mention of it (and rightly so) in any writing I have done on T2D, and will continue to do so. Ditto on my own personal disease analysis. For those of us who are severely insulin resistant (SIRDs - where 'merely' going LCHF and keto does not bring about a full remission) the free fatty acid 'thing' is a really important and interesting part of the mishaps in metabolism puzzle. She also talks about the fact that is her essential positive contribution to the talk and writing on metabolic disorders, and I think she is correct!
i would post links, but alas my old untrusty laptop with saved websites is on the blink, but I leave it up to any interested parties to read her articles on the subject of FFAs, due to laziness on my part.
I too don't understand her strong stand against Gary Taubes, I continue to use his work as standard references when talking about weight, and weight loss. Reading some of above in relation to her weight and weight loss experiences goes some way to explain it though, so thanks for that.
Re the neanderthal thing. Africans whose ancestors did not leave the cradle of humanity to go on to sexually mix and mingle with neanderthals and denisovans (excuse spelling,I can't be bothered spell checking), are notoriously prone to T2D, also, along with many other ethnic groups. So.... doubt it is the neanderthal gene thing.
My strong suspicion, and have read from others more learned on the subject than me, is that being prone to T2D is probably the norm for our species! As in it about fat storage pathways and response to a high carb food environment. And will become more and more 'normal' as our insane frankenfood environment does its damndest before we see sense and attack this metabolic mayhem at its source - our food sources. I live in a country, NZ, please note, where currently one third of the population has blood glucose dysregulation of some degree. This means prediabetic to diabetic levels, nationwide. And sadly, this country is not an isolated case across the globe.