I have got a lot of information from this paper, some I knew and understood, other more scientific knowledge and definitions, were a different view of how the body develops diabetes, especially NIDDM, as a description of non insulin dependent diabetes mellitus. The cause as I understand it is hyperinsulinaemia because of insulin resistance and the cycle of imbalance in the hormones. The number of hormones that influence the response to food, the glucose derived and the high amount of circulating insulin that has no effect on the glucose, glucagon response.
As the author suggests, the insulin/glucagon integral rein control by the hypothalamic-pituitary axis, with the growth hormone hGH, also the hormone somatostatin-28. I have read this called, the gut brain trigger.
In simple terms, how your hormonal response to food is triggered and the imbalance in amounts of the numerous hormones is why T2 diabetes happens.
Again, he quotes, the stimulus for the secretion of the incretins hormones- is food in the gastrointestinal tract, it anticipates and enhances the insulin response to glucose absorbed from the gut.
And importantly for those like me, any under or overshoot of anticipatory response is soon corrected by the integral rein control. The overshoot of insulin is why I hypo after a carb meal. Reactive Hypoglycaemia is resultant from the same causes and imbalance in response to food.
Homeostasis for me, is why I can live my life, in good health. My body is attuned to being in or just above normal levels, it has to be like this for me, the rollercoaster ride of blood sugar levels is the cause of the numerous symptoms. To be symptom and hypo free, I have to be in homeostasis.
Another point the article refers to is exercise and why despite exertion, people don't go hypo because of vigorous exercise. In my case, I cannot exercise in such manner, because I have found that the function that corrects my blood glucose levels as described in the article, does not apply to me, the glucose necessary for me from a liver dump would have the same effect as a carb laden meal and would trigger the onset of an overshoot of insulin as a response, which would mean an episode of hypoglycaemia.
As I said previously, it is a very good paper and the information I gleaned from it, has improved my understanding.
Thanks