GAD65 AB test results

atfsgeoff

Member
Messages
9
Hi folks!

Having recently been diagnosed as diabetic at 35 y/o with an A1C of 7.7%, I was sent home by my GP with no prescriptions but to watch my diet and see if I could lower it with diet alone. I then got an appointment with an endocrinologist who ordered four blood tests, those being:

GAD65 AB
IA2 AB
Insulin AB
Zinc Transporter 8 AB

I've received two of the four test results so far: GAD65 showed positive for elevated levels, mine being 32.2 U/mL where the listed standard is 5 U/mL or less. But my Insulin AB test came back completely negative, so I'm hopeful my other two labs will come back negative too.

I understand that positive GAD65 results typically mean type 1 or LADA, which I'm resigning myself to that probability. But in the meantime, I've had excellent results in keeping my blood sugar levels at completely normal ranges with just a low carb (<50g/day) diet. Having read a few other threads with folks posting results of GAD tests in the 1000s, I'm wondering if I can keep my AB levels at a low enough level so as not to destroy my beta cells or require insulin for as many years (maybe decades?) as I can get. I know this isn't really a thing anyone can know, as everyone's body chemistry and immune system is different for reasons not well understood. But I hope beyond hope that if I get tested again in say, 6 months or a year, that my GAD levels can stay as low as they already are or maybe even drop, with just improved diet. I know it's a long shot, but stranger things have happened.

I'm not good with needles or injections of any sort and even finger sticking a few times a day has me at my wit's end, the prospect of a lifetime of multiple insulin injections and finger sticks every day just has me a bit depressed. Sorry for troubling you all with my thoughts and possibly-irrational hopes in this early stage of my diagnosis.
 

JMoli

Well-Known Member
Messages
250
Type of diabetes
LADA
Treatment type
Insulin
Hi, I’m afraid I know so little as I’m newly diagnosed lada myself but just wanted to say hello. I understand the feelings about insulin injections for life, I had a really bad couple of days recently imagining that. For me personally I will have to (as much as I’ve tried to fight it!) but my results were very different from yours and I’m only just managing normalish blood sugar with the maximum dose of gliclazide and a lower carb diet. Anyway, I’m sure people will be able to help here
 

atfsgeoff

Member
Messages
9
Well, I guess another nail in the proverbial coffin is that my IA2 antibody test just came in, 120 U/mL. Normal range is <7.5U/mL. Guess I'm on the clock now.
 

JMoli

Well-Known Member
Messages
250
Type of diabetes
LADA
Treatment type
Insulin
Well, I guess another nail in the proverbial coffin is that my IA2 antibody test just came in, 120 U/mL. Normal range is <7.5U/mL. Guess I'm on the clock now.

Hi, do you know what happens next? How are you feeling? I don’t know any of my figures/levels yet and it looks a little complex! Anyway, hope you’re okay, it’s an emotional time
 

JPW1

Well-Known Member
Messages
60
Type of diabetes
LADA
Treatment type
Insulin
and it looks a little complex!

Yes it can be! I was diagnosed as type 2 in 2012......as a 60kg 42 year old....fast forward to December 2019 I'm on full basal bolus multiple daily injections and being treated as type 1. Oh, and negative for GAD antibodies.....though that may not have been the case in 2012, when I wasn't tested!

Don't worry about the injections most of the time completely painless, and well they're way better that the alternative! :) I've found it's just part of my life now, though I'm sure they'll be times when I get fed up. It'll take a few weeks to get the blood glucose levels down to normal so don't get frustrated.
 
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JMoli

Well-Known Member
Messages
250
Type of diabetes
LADA
Treatment type
Insulin
Yes it can be! I was diagnosed as type 2 in 2012......as a 60kg 42 year old....fast forward to December 2019 I'm on full basal bolus multiple daily injections and being treated as type 1. Oh, and negative for GAD antibodies.....though that may not have been the case in 2012, when I wasn't tested!

Don't worry about the injections most of the time completely painless, and well they're way better that the alternative! :) I've found it's just part of my life now, though I'm sure they'll be times when I get fed up. It'll take a few weeks to get the blood glucose levels down to normal so don't get frustrated.

Thanks, that’s so reassuring it’s painless and yes, better than the alternative :)
I’ve read that the blood sugars can be a bit erratic for a while, did you find that too? Do you follow a lower carb diet? I’d really prefer to do that and have the occasional carby meal (love Wagamamas) but concerned as I’m already very slim (currently a stone lighter than my original weight) I’ve just read Bright Spots and Landmines and find it so inspirational but I have such a fast metabolism I think I’d be stick thin if I ate what he does. Sorry to go off topic, it’s my current worry! (I rotate and refresh them!)
 

JPW1

Well-Known Member
Messages
60
Type of diabetes
LADA
Treatment type
Insulin
I’ve read that the blood sugars can be a bit erratic for a while, did you find that too? Do you follow a lower carb diet?

Mine were erratic for a couple of weeks but that was mainly due to the, wisely, slow introduction of insulin. I started on 2 units of long acting.....now on 12, and intially 2 units twice a day of fast acting - now a minimum of 4 morning 5 lunch and 7 at dinner, but that varies with what I'm eating, and you can add a few units here and there for snacks - so you can imagine if that's what it takes to keep me normal now just 1 month later, my bloods were pretty high on average until I got those doses up.

I do not consciously follow a low carb, but I am kind of lowish carb. Average/per day over the last few weeks has been about 160, but as I reintroduce my running etc. that will rise a bit.

I'm skinny 63kg and that's up a bit since (re) diagnosis in late December 2019 - so I'm not too worried about gaining a bit, once I'm back to my normal training load 300 carbs a day would be fine I think.
 

JMoli

Well-Known Member
Messages
250
Type of diabetes
LADA
Treatment type
Insulin
Mine were erratic for a couple of weeks but that was mainly due to the, wisely, slow introduction of insulin. I started on 2 units of long acting.....now on 12, and intially 2 units twice a day of fast acting - now a minimum of 4 morning 5 lunch and 7 at dinner, but that varies with what I'm eating, and you can add a few units here and there for snacks - so you can imagine if that's what it takes to keep me normal now just 1 month later, my bloods were pretty high on average until I got those doses up.

I do not consciously follow a low carb, but I am kind of lowish carb. Average/per day over the last few weeks has been about 160, but as I reintroduce my running etc. that will rise a bit.

I'm skinny 63kg and that's up a bit since (re) diagnosis in late December 2019 - so I'm not too worried about gaining a bit, once I'm back to my normal training load 300 carbs a day would be fine I think.

Were you on medication before the insulin and it had stopped keeping the blood sugars normal? Sorry if that’s nosy. I’ve got so much to learn with insulin and dosing, I’m hoping the nurse goes through it all very slowly with me this Tuesday.....
 

JPW1

Well-Known Member
Messages
60
Type of diabetes
LADA
Treatment type
Insulin
Medication:
Yes when I was diagnosed in 2012 I was put on 2 metformin and a glicazide...which were pretty much increased every year/six months until I maxxed out 2 years ago then some other tablet was added which helped a bit...but gave me bladder infections....then tried another which was an appetite inibitor (yep...on a 9 stone fella!)....all the time my HB1ac was creeping up I think last result was 79. At that stage I asked to be referred to specialist again which was no problem....she kind of took one look at me and said - you need insulin.

First stage was close monitoring of bloods before and 2 hours after every meal, which revealed an average BG of 12 or 13 and getting worse....stage two was removing glicazide (which boosts beta cell insulin production) - this made no difference i.e pretty much no insulin production it appears.

Stage 3 was Tresiba 2 units for three days...increasing every 3 or 4 days until waking and going to bed levels were normalish. It became pretty clear through keeping results that that basal insulin was not enough (nor near it) and I needed bolus insulin with my meals. Started off just with lunch and dinner....low does but as above my average I'd say now is 12 units of Tresiba (long acting) and 18-24 of Fiasp fast acting insulin with meals.

All of that took from the week before Christmas to about 2 weeks into the new year. It's a bit frustrating knowing you need more insulin but being "obedient" to advice! But while insulin in wonderful life saving stuff, the reality is you could kill yourself with it pretty easily.

I saw Dietitian on Friday and so I'm carb-counting now and dosing according to what I'm eating which is great. I'm getting on a DAFNE course at some stage in the future as well.

I found this a really useful document.