Many people will say that supplements are not usually required, though electrolytes like Magnesium can be very helpful. I personally think there is a massive benefit to some of the vitamins and things, like regular high dose Ascorbic Acid, Vitamin B3, Alpha Lipoic Acid, COQ10, Vitamin E, K2 & D3. Humans lost the ability to manufacture vitamin C in the body from glucose due to a missing enzyme. Carbohydrates interfere with the absorption of vitamin C as they compete for entry into the cells, but in the absence of carbohydrates vitamin C has better access. Furthermore, a guy called Lester Packer worked out there is an Antioxidant Network that plays out in the body. This network is C, E, Alpha Lipoic Acid, Glutathione, and COQ10. If you take ALA it boosts glutathione, but these elements all recycle each other - hence why they are a network.