Any word on Prof Roy Taylor's Retune Study ?

bulkbiker

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Ronancastled

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Cherry picking participants again then.

I would love to see the MRI of someone with a BMI of <20 with T2.
Just to see if his visceral fat theory holds water across all ranges.

I've seen Michael Mosleys scan here
https://thebloodsugardiet.com/michaels-story/

He was 86kg at diagnosis & I'd guess his height to be 5'10", that puts his BMI at 27.
All guesswork of course.
A 9kg weight loss worked for him giving him a new BMI of 24.
 

NicoleC1971

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This was to be his follow up to Direct
https://www.ncl.ac.uk/magres/research/diabetes/newstudy-retune/
https://www.diabetes.org.uk/researc...yorkshire/retuneing-type-2-diabetes-remission

The difference to the Direct Study is that the subjects were to have normal BMI to begin with.
Hoping to prove his PFT theory with TOFIs.

Anyone heard anything yet ?
According to the DuK briefing on research they were going ahead with it but as with all things DuK they are very vague and extremely centralised.
But given Direct is very much their baby and they are keen to promote remission via the Newcastle Diet above all other methods, I can't imagine they would not be funding this still and it is listed on their list of research projects.
 

NicoleC1971

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I wonder how they will be able to motivate quite slim people albeit with a tummy, to lose weight on 800 kcals where the only perceived benefit may be remission ? I understand that the shakes are the quickest way to prove the hypothesis and that they keep the food macros consistent.
I'd love to see an RCt in which patients were given sufficient calories to maintain their weight but where the carb ratios were tweaked. Then the scans could show differences in visceral fat alongside metabolic results.
 
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Speedbird

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They wouldn’t take me on. They said my BMI at 21 was too low. I thought they were looking for slim type 2s. Oh well.
 

MrsA2

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I wonder how they will be able to motivate quite slim people albeit with a tummy, to lose weight on 800 kcals where the only perceived benefit may be remission
My motivation was/is to prevent complications. I'm already partially sighted due to other reasons and would happily starve myself to retain the bit I have left.
Reading the report it's only 800 cals for 2 weeks at a time.
And, yes I would prefer to do it lc.

Does any one know, is it actually proven that tummy fat causes diabetes, or is it just a result of something else (insulin resistance?) going on?
I'm just wondering if this is another example of concentrating on symptoms rather than root causes
 

Dark Horse

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https://www.diabetes.org.uk/researc...yorkshire/retuneing-type-2-diabetes-remission
Finishing up Dec 21 - if the hypothesis is correct then this might be difficult to communicate given their previous emphasis on the magic 15k for weight loss and the whole idea that being obese causes diabetes that is widely promoted.
Actually, the Re-TUNE researchers hypothesize that it visceral fat that causes diabetes rather than being obese per se:-

"The cause of type 2 diabetes in non-obese people was thought to be different from in obese people, but results of experiments do not support this view. An alternative idea is that people have a personal level of total body fat that they can tolerate and if they go above that level, they develop diabetes. Re-TUNE will study whether weight loss in people with type 2 diabetes who are not obese can reverse their condition, which would support the idea of a personal fat threshold." https://www.dtu.ox.ac.uk/OurTrials/ReTune.php
 

Ronancastled

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Bit more detail here:
https://www.eurekalert.org/news-releases/929487

Average weight fell by 8.2kg, from 69kg to 61.8kg – a reduction of 11.9%. Total body fat fell from 33.1% to 27.4%. This compares to a figure of 25.4% for the controls.

Scans showed that the average amount of fat in the liver fell from 4.4% - more than twice as high as in the controls – to 1.4%.

Fat in the pancreas fell from an average of 5.1% to 4.5%. Average levels of triglycerides (plasma TG, a measure of fat metabolism efficiency) fell dramatically from 1.6mmol/L to 1.0mmol/L – on a par with the controls.
 

Dark Horse

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They wouldn’t take me on. They said my BMI at 21 was too low. I thought they were looking for slim type 2s. Oh well.
As they are aiming for a 10-15% weight-loss, it's likely that with your BMI you would end up as being underweight which wouldn't be ethical:-

"People on the ReTUNE trial are being asked to consume 800 calories a day (from soups, shakes and non-starchy vegetables) for up to two weeks while being supervised by a medical team. After this, they are supported to gradually return to eating normal food and to keep off the weight they lost.

This cycle of a low-calorie diet and weight loss maintenance is repeated up to three times, until they have lost 10-15% of their body weight. After each cycle, the research team is measuring the amount of fat in the pancreas and liver and looking to see who has gone into remission." https://www.diabetes.org.uk/about_u...r&utm_campaign=retune_preview&utm_term=280921
 

LaoDan

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The term “new normal “
Seems like a disastrous diet. Protect lean mass at all costs. Alternating weeks of maintenance/protein sparing modified fasting would be much safer/manageable.

anyone know the macros of the shakes?