I've been on Bydureon for a few months now - it had little effect on BS levels until around 6 weeks but now is very effective in keeping levels down. You've got to be patient and let its effectiveness build up, like it says in the accompanying literature.
I've had side-effects - indigestion, constipation and occasional nausea. Not very pleasant, but I'm sticking with it to see if the side-effects diminish with time, like some people say they will.
You are bound to get lumps under the injection site - you are not injecting a liquid, but a suspension, I.e. a liquid with tiny solid particles in it. My experience is that the lumps gradually disappear after 4/5 weeks and don't cause any discomfort. The fact that you are injecting a suspension is the reason why you get 2 needles in each Bydureon injection pack, in case one gets blocked with the solid particles if the injection was not mixed properly.
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