Hi Karen G, I have just read your post about being diagnosed with peripheral neuropathy and I sympathise with you . I have suffered with it for years now, at first it was my feet and lower legs, then my torso, now my shoulders, arms and hands. I also have H.A.V.S. which is hand, arm, vibration syndrome, which was brought on by using vibration equipment while I was working in the construction industry. I take Neurontin, Pregablin, Duloxetine, and quite a few other medications for blood pressure, cholesterol, etc the three mentioned are for control of the really bad pain I get in the areas mentioned. The worst pain is easily in my feet, taking the medications really do help with the pain and without them I am unable to walk because of the intense pain. My prescription was lost by the chemist not long ago so I was a week late in getting my prescription, the first couple of days weren't that bad because I think the medication was still in my blood, but the third day and on until I got the prescription were bloody terrible, with pain I can't describe. The Duloxetine was prescribed for my depression but if you read the notes with it, it also works as a painkiller.In summary Karen, they do work to stop the pain and I know I can't do without them now, I now get my medication in blister packs because I was like you I gave up as well but for longer than you, I was hoping something serious would happen to me and end this hell of diabetes. But I am back doing as I am told because of my family pleadings, hope this helps, and things get better . Tom D