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Any other type 1's take SGLT 2 or dapagliflozin?

Discussion in 'Type 1 Diabetes' started by megan, Oct 2, 2020.

  1. megan

    megan Type 1 · Well-Known Member

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    Interested to know if there are any type 1's on here who take SGLT 2 or dapagliflozin?
     
  2. NicoleC1971

    NicoleC1971 Type 1 · Well-Known Member

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    In the UK I was told it was not licensed for type 1 though I did think it might be useful.
    Do you?
     
  3. Oldvatr

    Oldvatr Type 2 · Expert

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    This is an article published in the USA and there is also an FDA advisory (actually there are several) on this class of medication that is not reflected in the UK
    https://care.diabetesjournals.org/content/42/6/991

    NICE does allow prescription for use with T1D in the UK.
    https://www.diabetes.co.uk/news/201...in-as-type-1-diabetes-treatment-98662251.html

    You will notice that although the NICE does mention DKA, it does not warn of the danger that the specific euDKA variant that this drug initiates . There is also no warning about the Fournier's gangrene or the potential cardio problems noted by the FDA regarding use in patients with kidney disease or using loop diuretics where they recommend frequent blood tests and support

    Note the use of wee stix to measure glucose levels OR ketone levels in the wee are interfered with by this medication and should not be used for control.
     
  4. MarkMunday

    MarkMunday Type 1 · Well-Known Member

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    SGLT2 inhibitors remove glucose from the bloodstream by pushing it out through the kidneys. Kidneys were not designed for this. Interfering with their delicate function is not a good idea IMHO. Insulin is a much better tool for removing glucose from the bloodstream. It just means eating appropriate amounts of carbohydrate.
     
  5. megan

    megan Type 1 · Well-Known Member

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    Thanks for your reply's
     
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  6. megan

    megan Type 1 · Well-Known Member

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    No I don't. I'm type 1 in insulin pump and max dose metformin. Low to no carb doesn't make a huge amount of difference to my control or insulin levels. One of those apparently unique cases the drs day. Currently on 16:8 eating regime. Was in 500-800 calories a day now more like 1200.
    Offered byetta for the second time. Last time was 9 years ago and it made me very sick.
     
  7. Oldvatr

    Oldvatr Type 2 · Expert

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    Make sure you can measure blood ketone levels (not using wee stix), keep hydrated, watch your sensitive bits for any signs of change, and deal with any UTI's promptly. Not a med I would use myself, but if it works for you, then hope it treats you well. Maybe get a medical charm or laminated card to warn of euDKA just in case coz not all paramedics are trained in this.
     
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  8. kareeta

    kareeta Type 1 · Well-Known Member

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    I've been taking 5mg Forxiga (Dapagliflozin) on and off for around two years now. At first I had lots of thrush and UTI's and then it settled down and I realised it only works if you are relatively low carb anyway, It definitely lowered my levels. No weight loss, but I did feel more in control when taking it.
     
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