1. Get the Diabetes Forum App for your phone - available on iOS and Android.
    Dismiss Notice
  2. Guest, we'd love to know what you think about the forum! Take the Diabetes Forum Survey 2022 »
    Dismiss Notice
  3. Diabetes Forum should not be used in an emergency and does not replace your healthcare professional relationship. Posts can be seen by the public.
    Dismiss Notice
Dismiss Notice
Find support, ask questions and share your experiences. Join the community »

Type 2 C-Peptide: can it be recovered?

Discussion in 'Ask A Question' started by andre53, Oct 29, 2021.

  1. andre53

    andre53 · Active Member

    Messages:
    36
    Likes Received:
    54
    Trophy Points:
    18
    C-peptide is a blood exam usually applied for type 2 diabetics to help doctors to decide if they need to add insulin injections for the therapy treatment(1).

    Ketogenic diet as type 2 diabetes therapy has helped me so much that I need to tell a doctor I am a T2 patient because blood tests do not show the disease (HbA1c, insulin, and fast blood glucose).

    I am at T2 since 2011, but measuring my C-peptide, I've read a surprising 3,44 ng/mL(2) which is by far a healthy number. T2 patients who needs to add insulin injections in their treatment usually show numbers below 0,5 ng/ml.

    My question is: if I did not made mistakes in my statements, do you know, nice people if it is possible to recover C-peptide numbers during a ketogenic therapy?

    (1) please, feel free to correct me if my statement is wrong
    (2) sorry, I don't know european units for this measurement
     
  2. LaoDan

    LaoDan Type 2 · Well-Known Member

    Messages:
    927
    Likes Received:
    594
    Trophy Points:
    153
    Never had this test, but I believe there’s a study where losing visceral fat can help the pancreas.
     
    • Like Like x 1
  3. Goonergal

    Goonergal Type 2 · Master

    Messages:
    12,816
    Likes Received:
    19,627
    Trophy Points:
    298
    My understanding is that the c-peptide test is used - alongside other tests - to distinguish between type 1 and type 2 diabetes, rather than to decide on insulin use in type 2s.

    A type 1 diagnosis would lead to prescription of insulin.

    Most type 2s produce too much insulin as it is not working efficiently due to insulin resistance. A ketogenic diet can help to reduce insulin resistance.
     
    • Like Like x 3
    • Agree Agree x 1
  4. bulkbiker

    bulkbiker Type 2 · Oracle

    Messages:
    18,969
    Likes Received:
    12,570
    Trophy Points:
    298
    Hi @andre53

    Your c-peptide shows that you are still an insulin overproducer and so still T2.

    Screenshot 2021-10-29 at 09.09.15.png

    From here https://www.diabetes.co.uk/c-peptide-test.html

    In my view if you have a c-peptide result of 0.5 ng/mL then you are not a T2 but one of the T1 variants.

    Your ketogenic diet will definitely help to reduce insulin over production but it may take a long time before completely recovering normal levels.
     
    • Like Like x 1
  5. ert

    ert Type 1 · Well-Known Member

    Messages:
    2,499
    Likes Received:
    3,018
    Trophy Points:
    198
    The c-peptide result of less than 0.2 ng/ml (80 pmmol/L) but only in the first 5 years is type 1. After that, you still type 2 when your insulin production falls.

    https://www.exeterlaboratory.com/test/c-peptide-plasma/
     
    • Like Like x 1
  6. bulkbiker

    bulkbiker Type 2 · Oracle

    Messages:
    18,969
    Likes Received:
    12,570
    Trophy Points:
    298
  7. ert

    ert Type 1 · Well-Known Member

    Messages:
    2,499
    Likes Received:
    3,018
    Trophy Points:
    198
    It's what the specialists are using and it's life-changing for some to get a clear diagnosis:
    https://www.exeter.ac.uk/news/featurednews/title_707155_en.html

    "Professor Mark Strachan, from Western General Hospital, Edinburgh, said: “We have now measured C-peptide in over 750 people with a clinician-diagnosis of Type 1 diabetes, attending our clinic at the Westen General Hospital. So far, we have made a new diagnosis of genetic diabetes in eight people, and changed the diagnosis to Type 2 diabetes in 28 other people. This has allowed us to make changes to treatment in many of these individuals and in 12 people we have actually been able to stop insulin therapy.”"

    @andre53 needs to take medical advice based on his c-peptide but it would be wonderful to possibly not need insulin.
     
    • Like Like x 1
  8. bulkbiker

    bulkbiker Type 2 · Oracle

    Messages:
    18,969
    Likes Received:
    12,570
    Trophy Points:
    298
    Amazing how poor the NHS is at diagnosing.

    T2's are insulin overproducers and should really never be prescribed yet more but....
     
    • Agree Agree x 1
    • Informative Informative x 1
  9. Mr_Pot

    Mr_Pot Type 2 · Well-Known Member

    Messages:
    4,575
    Likes Received:
    2,091
    Trophy Points:
    178
    Complex things seem simple to those with a little knowledge, no training and no experience.
     
  10. bulkbiker

    bulkbiker Type 2 · Oracle

    Messages:
    18,969
    Likes Received:
    12,570
    Trophy Points:
    298
    Seems to be bourne out by the study results though...

    "We have now measured C-peptide in over 750 people with a clinician-diagnosis of Type 1 diabetes, attending our clinic at the Westen General Hospital. So far, we have made a new diagnosis of genetic diabetes in eight people, and changed the diagnosis to Type 2 diabetes in 28 other people. This has allowed us to make changes to treatment in many of these individuals and in 12 people we have actually been able to stop insulin therapy."
     
  11. Daibell

    Daibell LADA · Master

    Messages:
    12,392
    Likes Received:
    7,351
    Trophy Points:
    298
    Agreed. I can see no difference between someone who is T1 thru antibodies and someone who now has low insulin for whatever reason. Whatever type you use to define them the clinical reason is the surely the same - dead beta cells.
     
  12. bulkbiker

    bulkbiker Type 2 · Oracle

    Messages:
    18,969
    Likes Received:
    12,570
    Trophy Points:
    298
    Under production and over production are the means of distinguishing T1(and its variants) and T2 in my opinion.

    T2 is hyperinsulinaemia and it would appear that many doctors are coming to that conclusion.

    Shame c-pep is rarely tested or used for diagnosis in the vast majority of cases in the UK at the moment, we can but hope in future it will be used more often.
     
  13. HSSS

    HSSS Type 2 · Expert

    Messages:
    5,892
    Likes Received:
    2,895
    Trophy Points:
    198
    It actually says unlikely. I would guess low carb or keto may extend the honeymoon especially in a LADA type 1 and they would be the exceptions to the rule. I wouldn’t expect it’s something they come across that often.
     
  14. searley

    searley Type 1 · Moderator
    Staff Member

    Messages:
    1,747
    Likes Received:
    666
    Trophy Points:
    173
    cpeptide is a molecule that is attached to the insulin molecule so is released at the same time as the insulin.. cpeptide stays in the blood for longer than insulin which is why testing for insulin production cpeptide is normally tested as more cpep means more insulin

    so the question is not can cpeptide be recovered... it's whether insulin production can be recovered

    and in most cases I would say probably not
     
  15. Ronancastled

    Ronancastled Type 2 · Well-Known Member

    Messages:
    1,001
    Likes Received:
    629
    Trophy Points:
    173
  • Meet the Community

    Find support, connect with others, ask questions and share your experiences with people with diabetes, their carers and family.

    Did you know: 7 out of 10 people improve their understanding of diabetes within 6 months of being a Diabetes Forum member. Get the Diabetes Forum App and stay connected on iOS and Android

    Grab the app!
  • Tweet with us

  • Like us on Facebook