- Messages
- 417
- Type of diabetes
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- Diet only
Low carb GP Dr David Unwin makes prestigious list of influential GPs in the UK
From here:
https://www.diabetes.co.uk/news/201...st-of-influential-gps-in-the-uk-91444560.html
It ends saying "Also, among his achievements, he was asked to contribute to Diabetes UK's dietary guidelines for 2018."
That's sounds good - they could do with the help. (However, did they use his contribution?) Here's the prior "Position statement - Low-carb diets for people with diabetes" from Diabetes UK:
https://www.diabetes.org.uk/resources-s3/2017-09/low-carb-diets-position-statement-May-2017.pdf
It says "Most carbohydrates are broken down into glucose which is an essential fuel for the brain [2]." which I suppose is meant to infer we need to eat carbohydrate?
Reference 2 is: Mergenthaler P, Lindauer U., Dienel G. A, Meisel A. (2013). Sugar for the brain:the role of glucose in physiological and pathological brain function. Trends Neurosci. 2013 Oct;36(10):587-97.
The paper begins "The mammalian brain depends upon glucose as its main source of energy...". The paper then describes Ketogenic diets as being "a diet that has a high fat and low carbohydrate content so that plasma levels of ketone bodies (acetoacetate and β-hydroxybutyrate) rise and serve as an alternative oxidative fuel." So another fuel does exist, namely β-hydroxybutyrate. Perhaps the brain doesn't depend on glucose for the main source of energy, then?
(After a few weeks on a Keto diet, the brain adapts to using ketones bodies and research has found that the astrocytes in the brain and spinal cord can also produce ketone bodies, which can be used as substrates for neuronal metabolism: https://www.ncbi.nlm.nih.gov/pubmed/14769487 Brain fuelled by ketones: https://www.ncbi.nlm.nih.gov/pubmed/27826689)
The paper in question doesn't, though, mention gluconeogenesis (as far as I can see) where the body will make whatever glucose it needs. Erythrocytes (red blood cells) have not got mitochondria to metabolize fatty acids/ketones so do need glucose. I gather the brain possibly needs 25% glucose?
If "The mammalian brain depends upon glucose as its main source of energy" were true, then what would happen to the brains of people who eat almost no carbs on a Keto diet prescribed for epilepsy, say, which is a treatment approved of by the paper?
Either way, people do not need to eat carbohydrate, so the implication that they do by Diabetes UK seems somewhat misleading and isn't even scientifically backed-up by the paper they cite.
Or am I misunderstanding something?
From here:
https://www.diabetes.co.uk/news/201...st-of-influential-gps-in-the-uk-91444560.html
It ends saying "Also, among his achievements, he was asked to contribute to Diabetes UK's dietary guidelines for 2018."
That's sounds good - they could do with the help. (However, did they use his contribution?) Here's the prior "Position statement - Low-carb diets for people with diabetes" from Diabetes UK:
https://www.diabetes.org.uk/resources-s3/2017-09/low-carb-diets-position-statement-May-2017.pdf
It says "Most carbohydrates are broken down into glucose which is an essential fuel for the brain [2]." which I suppose is meant to infer we need to eat carbohydrate?
Reference 2 is: Mergenthaler P, Lindauer U., Dienel G. A, Meisel A. (2013). Sugar for the brain:the role of glucose in physiological and pathological brain function. Trends Neurosci. 2013 Oct;36(10):587-97.
The paper begins "The mammalian brain depends upon glucose as its main source of energy...". The paper then describes Ketogenic diets as being "a diet that has a high fat and low carbohydrate content so that plasma levels of ketone bodies (acetoacetate and β-hydroxybutyrate) rise and serve as an alternative oxidative fuel." So another fuel does exist, namely β-hydroxybutyrate. Perhaps the brain doesn't depend on glucose for the main source of energy, then?
(After a few weeks on a Keto diet, the brain adapts to using ketones bodies and research has found that the astrocytes in the brain and spinal cord can also produce ketone bodies, which can be used as substrates for neuronal metabolism: https://www.ncbi.nlm.nih.gov/pubmed/14769487 Brain fuelled by ketones: https://www.ncbi.nlm.nih.gov/pubmed/27826689)
The paper in question doesn't, though, mention gluconeogenesis (as far as I can see) where the body will make whatever glucose it needs. Erythrocytes (red blood cells) have not got mitochondria to metabolize fatty acids/ketones so do need glucose. I gather the brain possibly needs 25% glucose?
If "The mammalian brain depends upon glucose as its main source of energy" were true, then what would happen to the brains of people who eat almost no carbs on a Keto diet prescribed for epilepsy, say, which is a treatment approved of by the paper?
Either way, people do not need to eat carbohydrate, so the implication that they do by Diabetes UK seems somewhat misleading and isn't even scientifically backed-up by the paper they cite.
Or am I misunderstanding something?