Drug induced diabetes

Alexandra100

Well-Known Member
Messages
3,738
Type of diabetes
Prediabetes
Treatment type
Tablets (oral)
From PubMed

Drug Saf. 2015 Dec;38(12):1153-68. doi: 10.1007/s40264-015-0339-z.
Drug-Induced Hyperglycaemia and Diabetes.
Fathallah N1,2, Slim R3, Larif S3, Hmouda H4, Ben Salem C3.
Author information

Abstract
Drug-induced hyperglycaemia and diabetes is a global issue. It may be a serious problem, as it increases the risk of microvascular and macrovascular complications, infections, metabolic coma and even death. Drugs may induce hyperglycaemia through a variety of mechanisms, including alterations in insulin secretion and sensitivity, direct cytotoxic effects on pancreatic cells and increases in glucose production. Antihypertensive drugs are not equally implicated in increasing serum glucose levels. Glycaemic adverse events occur more frequently with thiazide diuretics and with certain beta-blocking agents than with calcium-channel blockers and inhibitors of the renin-angiotensin system. Lipid-modifying agents may also induce hyperglycaemia, and the diabetogenic effect seems to differ between the different types and daily doses of statins. Nicotinic acid may also alter glycaemic control. Among the anti-infectives, severe life-threatening events have been reported with fluoroquinolones, especially when high doses are used. Protease inhibitors and, to a lesser extent, nucleoside reverse transcriptase inhibitors have been reported to induce alterations in glucose metabolism. Pentamidine-induced hyperglycaemia seems to be related to direct dysfunction in pancreatic cells. Phenytoin and valproic acid may also induce hyperglycaemia. The mechanisms of second-generation antipsychotic-associated hyperglycaemia, diabetes mellitus and ketoacidosis are complex and are mainly due to insulin resistance. Antidepressant agents with high daily doses seem to be more frequently associated with an increased risk of diabetes. Ketoacidosis may occur in patients receiving beta-adrenergic stimulants, and theophylline may also induce hyperglycaemia. Steroid diabetes is more frequently associated with high doses of glucocorticoids. Some chemotherapeutic agents carry a higher risk of hyperglycaemia, and calcineurin inhibitor-induced hyperglycaemia is mainly due to a decrease in insulin secretion. Hyperglycaemia has been associated with oral contraceptives containing high doses of oestrogen. Growth hormone therapy and somatostatin analogues may also induce hyperglycaemia. Clinicians should be aware of medications that may alter glycaemia. Efforts should be made to identify and closely monitor patients receiving drugs that are known to induce hyperglycaemia.

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Guzzler

Master
Messages
10,577
Type of diabetes
Type 2
Treatment type
Diet only
Dislikes
Poor grammar, bullying and drunks.
And yet *their* number one cited associative cause for T2 is 'Poor Lifestyle Choices'. Pfft!
 

Rachox

Oracle
Retired Moderator
Messages
15,810
Type of diabetes
I reversed my Type 2
Treatment type
Tablets (oral)
I’ve just been able to drop one of my BP meds as with my weight loss etc my bp has become normal. It was a calcium channel blocker and my daily average bloods sugars has reduced noticeably. So in turn at my next review I may be able to reduce my Metformin. You can easily see how less informed or less interested people might just end up taking more and more tablets to combat the effects of each other. My aim is to do the opposite!
 

Guzzler

Master
Messages
10,577
Type of diabetes
Type 2
Treatment type
Diet only
Dislikes
Poor grammar, bullying and drunks.
I’ve just been able to drop one of my BP meds as with my weight loss etc my bp has become normal. It was a calcium channel blocker and my daily average bloods sugars has reduced noticeably. So in turn at my next review I may be able to reduce my Metformin. You can easily see how less informed or less interested people might just end up taking more and more tablets to combat the effects of each other. My aim is to do the opposite!

If you had not been diagnosed with T2 would it have occurred to you to ask your GP whether there was a risk of developing the condition with each medicine you were prescribed? I certainly would never have asked because T2 was not on my radar.
 
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Rachox

Oracle
Retired Moderator
Messages
15,810
Type of diabetes
I reversed my Type 2
Treatment type
Tablets (oral)
If you had not been diagnosed with T2 would it have occurred to you to ask your GP whether there was a risk of developing the condition with each medicine you were prescribed? I certainly would never have asked because T2 was not on my radar.

No I wouldn’t! My type 2 diagnosis has made me much more aware of all the medicines I take. Even being a nurse (retired now) I did just tend to blindly take everything I was prescribed without much thought. Not now!
 

Guzzler

Master
Messages
10,577
Type of diabetes
Type 2
Treatment type
Diet only
Dislikes
Poor grammar, bullying and drunks.
No I wouldn’t! My type 2 diagnosis has made me much more aware of all the medicines I take. Even being a nurse (retired now) I did just tend to blindly take everything I was prescribed without much thought. Not now!

That is why I think this site Rocks! I have learned so much here and one of the most important things is what questions to ask. We live and learn. :)
 

Rachox

Oracle
Retired Moderator
Messages
15,810
Type of diabetes
I reversed my Type 2
Treatment type
Tablets (oral)
That is why I think this site Rocks! I have learned so much here and one of the most important things is what questions to ask. We live and learn. :)
You’re right, I don’t think it was my diagnosis per se that’s made me question things more, it was coming to this Forum! It does indeed rock! :)
 

alf_Josiah

Well-Known Member
Messages
2,895
Type of diabetes
Type 2
Treatment type
Insulin
Dislikes
People that point out my spelling mistakes
One should always question the doctors. This philosophy has kept me alive.