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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

Discussion in 'Diabetes Discussions' started by Oldvatr, Feb 24, 2017.

  1. Oldvatr

    Oldvatr Type 2 · Expert

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  2. kokhongw

    kokhongw I reversed my Type 2 · Well-Known Member

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    Latest promising study on Beta Cells regeneration by Dr Valter Longo
    http://www.bbc.com/news/health-39070183
    [​IMG]

    http://www.cell.com/cell/fulltext/S0092-8674(17)30130-7

    PDF version
    http://www.cell.com/cell/pdf/S0092-8674(17)30130-7.pdf
     
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    #2 kokhongw, Feb 24, 2017 at 3:44 AM
    Last edited: Feb 24, 2017
  3. Kristin251

    Kristin251 LADA · Expert

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    I've read many studies that a low cal diet, especially low carb and moderate protein Mimick fasting. That's pretty much the diet I eat. Around 1000 Cals, all nutrient dense. Of course I'm type one now so not going to restore my pancreas but allows very small doses of insulin. Weight and muscles holding for years.
     
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  4. kokhongw

    kokhongw I reversed my Type 2 · Well-Known Member

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    The difference in what Dr Valter Longo propose is the cycling of the Fasting Cycle. A continuous low calorie/low carb diet does not promote cells regeneration. There needs to be a fast/feed cycle...that is what makes this study promising...hopefully it can be replicated.
     
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  5. Kristin251

    Kristin251 LADA · Expert

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    Well as a type one that produces measly amounts of insulin it won't reverse me however, when very strict low carb, low protein and mostly plant fats like avocado I will say I am much more insulin sensitive. I concur with the low saturated fat !!! They make me IR. NO dairy or fatty meats or I require much ,ore I sulin at the time of food as well as the next day. Overeating protein beyond my needs as well and of course carbs!!
     
  6. Indy51

    Indy51 Type 2 · Expert

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  7. kokhongw

    kokhongw I reversed my Type 2 · Well-Known Member

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    The study suggest it may work for T1D
    •Cycles of FMD reverse β-cell failure and rescue mice from T1D and T2D
    •Inhibition of PKA or mTOR promotes Ngn3-driven β-cell regeneration in human T1D islets

    Had posted a separate thread.
    http://www.diabetes.co.uk/forum/thr...cell-regeneration-to-reverse-diabetes.116847/
     
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  8. Kristin251

    Kristin251 LADA · Expert

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    Too scientific for me but I do inhibit the mTor pathway by keeping my protein at the right amount and no higher nor more than 21g per meal. The mTor pathway is the pathway to disease. Since I have reduced protein my bs is more stable. I learnned this first from dr Ron Rosedale. His book was a very inspiring read

    I've eaten less than 20 g carbs per day and most fats are avocado, olive oil and nuts/ pumpkins seeds. Some mayo too
     
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  9. kokhongw

    kokhongw I reversed my Type 2 · Well-Known Member

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    The main concept that Valter Longo propose which differs from the usual low carb is the idea of cycling the fasting/refeeding period. The fasting starts the autophagy process, clearing away the damage cells, the proper refeeding allows new cells to be generated.

    That's my take away from his various interviews and studies...

    Cycles of FMD reverse β-cell failure and rescue mice from T1D and T2D

    In this interview he highlights it is the refeeding that rebuilds the system. From 03:00 onwards..
     
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    #9 kokhongw, Feb 24, 2017 at 4:50 AM
    Last edited: Feb 24, 2017
  10. tim2000s

    tim2000s Type 1 · Expert
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    It's all very well regenerating beta cells, but without stopping the T-Cell attack on them, you can't really eliminate T1D.

    It might provide a mechanism by which beta cell regeneration can be accelerated following an effective way to shut down that attack though, or potentially, future research might look at whether the introduction of the diet itself has a similar effect.
     
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  11. GrantGam

    GrantGam Type 1 · Well-Known Member

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    Popped Sky News on around 0715 and the reporter was mid discussion with a GP about a mice study that apparently reversed BOTH types of diabetes...

    From what I picked up (half asleep) was that the whole thing was based on a heavily restricted calorie intake, around 10% of the recommended - 200-250kcal.

    She kept referring to both type 1 and type 2 diabetes and the possibility of reversal and no further need for insulin injections. She outlined the differences between the two conditions so is more than aware of their dissimilarities, especially regarding the cause.

    I can't help but consider that this woman is bat **** nuts though. Pre insulin discovery, T1D's would go on a near starvation diet and would still die very quickly.

    I understand this is a "study" but I don't like seeing this sort of thing in the news as it"s pure nonsense IMO.

    Did anyone else catch it on the news this morning?
     
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  12. db89

    db89 Type 1 · Well-Known Member

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  13. azure

    azure Type 1 · Expert

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    It sounds quite vague. As @GrantGam says, starvation diets were a common treatment before insulin. I remember reading about a black coffee and whisky one (the whisky was added to dull the pain of starvation). All Type 1s died before insulin, despite their starvation diets.

    I'm quite sceptical because previous comments like that that I've read have been disappointing when investigated further. And usually just mean the people with Type 1 have been able to reduce their insulin. That's fine but not a cure.

    And, of course, presumably the newly regenerated beta cells would be attacked and killed by the immune system in Type 1s.
     
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  14. mist

    mist · Guest

    Poor Mr mouse :(

    The whole thing smells fisher than batteries fish market!
     
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  15. "People spend five days on a low calorie, low protein, low carbohydrate but high unsaturated-fat diet.

    Then they have 25 days eating what they want - so overall it mimics periods of feast and famine."


    Wow. Will have to have a proper read later. Thanks for posting.
     
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  16. geefull

    geefull Type 2 (in remission!) · Well-Known Member

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    The actual quotes the BBC uses from the doctor say that 'you can use diet to reverse the symptoms of diabetes' and it's in a mouse model, so it hardly seems to warrant the hyped headlines (yet at least).

    The doctor (Dr. Longo) also mentions 'reprogramming' beta cells, which is very different from 'regenerating' them (which the Beeb mention earlier) although he also says 'rebuild' which I agree is closer to regenerating but he uses it in the context of rebuilding the part of the pancreas which is no longer functioning (but would obviously still need to exist) , regenerating implies creating new cells, reprogramming implies improving those that (still) exist.

    Worrying because it gives non diabetics the impression that diabetes can be 'fixed' and as for using diet to control diabetes and improve the functioning of our remaining beta cells, a lot of us here work to do that :)
     
  17. Harrysdad

    Harrysdad Type 1 · Well-Known Member

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  18. LAR

    LAR Type 2 · Well-Known Member

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    #18 LAR, Feb 24, 2017 at 9:23 AM
    Last edited: Feb 24, 2017
  19. kokhongw

    kokhongw I reversed my Type 2 · Well-Known Member

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    Valter Longo's team had an earlier report last year on how that may work...no one is sure at this point, but at least there is some progress...

    Diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899145/
     
  20. zand

    zand Type 2 · Expert

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    Thanks for posting this. :)
     
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