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FDA alert about SGLT2 Inhibitors

Discussion in 'Type 2 Diabetes' started by Irene Banting, Oct 31, 2018.

  1. Irene Banting

    Irene Banting Type 1 · Member

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    • Informative Informative x 2
    #1 Irene Banting, Oct 31, 2018 at 9:48 AM
  2. Guzzler

    Guzzler Type 2 · Master

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    There have been a coupla threads about SGLT2 inhibitors wrt to low carb diets and the risk of DKA. I have to admit that if/when I have to add stronger drugs (Metformin only atm) these family of drugs will not be my first choice.
     
    #2 Guzzler, Oct 31, 2018 at 1:00 PM
  3. NicoleC1971

    NicoleC1971 Type 1 · Well-Known Member

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    They are trying to get these class of drugs approved for type 1 diabs who have a large post prandial spike in glucose but it will be contraindicated for those with a history of getting into ketoacidosis easily...
    In my 36 year 'career' this has only happened to me twice? And I have had some hideously high blood sugars.
    I was interested because this class of drugs gets you to expel glucose via the kidneys in tpe 2s and in type 1 inhibits the take up of glucose into the blood plus they are linked to an improvement in renal and cardiovascular outcomes.
    However I would very much prefer not to need them and get my HBA1c down using my new toy (freestyle libre)!
     
    #3 NicoleC1971, Oct 31, 2018 at 1:48 PM
  4. Irene Banting

    Irene Banting Type 1 · Member

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    The link is in relation to an alert about this class of drug causing a rare and serious genital infection called necrotising fasciitis of the perineum, not about the usual action of the medication. It sounds awful, and really strange. I have never heard of such a thing before!
     
    #4 Irene Banting, Oct 31, 2018 at 2:51 PM
  5. Guzzler

    Guzzler Type 2 · Master

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    This has also been reported here on the forum.
     
    #5 Guzzler, Oct 31, 2018 at 4:12 PM
  6. Indy51

    Indy51 Type 2 · Expert

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    #6 Indy51, Oct 31, 2018 at 9:39 PM
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