You should not give a glucagon injection into the vein, the kits are specific for leg or arm, or bum or stomach, anywhere on the body and no need to remove clothes, I have had it via IV at the hospital, it make you VOMIT INSTANTLY. I have been given it as part of a Clamp Test otherwise it is not recommended. The instructions for use are in the box. My daughter has used it following the instructions as had my mum. Having suffered severe hypoglycemia over many years Glucagon and I are very good friends. Normally only take 15 minutes to work though I have received on occasion 2 shots.