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Harvard team "cures" diabetes in mice with stem cells; a similar clinical trial is lauched by others

Discussion in 'Diabetes Research' started by bookbah, Oct 26, 2014.

  1. bookbah

    bookbah Researcher · Newbie

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    In a world-first, Harvard University's Doug Melton reported in a top journal "curing" diabetes in mice using both embryonic and adult stem cells, meticulously creating perfect beta cells that respond repeatedly to insulin. A similar approach by a different and unrelated group, involving stem cells that were differentiated to slightly less mature beta cells than Melton's before implant, is at the heart of a clinical trial in Type 1 patients. http://www.biosciencetechnology.com/articles/2014/10/embryonic-stem-cells-trial-diabetes
     
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  2. SamJB

    SamJB Type 1 · Well-Known Member

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    Amazing. They're starting human trials in a few weeks. I'm very confident that there will be a cure, or a closed loop system, available to us in the next 5 years or so.
     
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  3. Emmotha

    Emmotha Type 1 · Well-Known Member

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    Hello
    Might be a daft question, but won't our antibodies just kill them off again?
     
  4. SamJB

    SamJB Type 1 · Well-Known Member

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    They say that they're planning to put the cells in a capsule that blocks immune cells from entering. Doesn't mention whether this capsule has been invented yet!
     
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  5. daniT1D

    daniT1D Type 1 · Well-Known Member

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    Yeah I read it needs to go in a capsule which they haven't even started to develop!


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  6. SamJB

    SamJB Type 1 · Well-Known Member

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    Ah. Slight stumbling block there. Sounds like the hard bit has been done. I suppose the could put it into a porous capsule, with holes smaller than a white blood cell. Who knows!?
     
  7. daniT1D

    daniT1D Type 1 · Well-Known Member

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    I also loved the quote "4 months after transplant only 1 of the 6 mice had died" :O


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  8. PaulinaB

    PaulinaB Type 1 · Well-Known Member

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    Oh my god! :D

    I guess even if your immune system kills them, you can have another implant! Even if that's every year, I'd go for one procedure per year instead of X insulin injections per day ;)
     
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  9. LucySW

    LucySW Type 1 · Well-Known Member

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    But Sam, wouldn't this mean immunosuppressants for life? I'd prefer insulin to that.
     
  10. kitty55

    kitty55 Type 1 · Well-Known Member

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    Don't think so cos if they're encapsulated I don't think you need immunosuppressants. Or am I wrong?
     
  11. SamJB

    SamJB Type 1 · Well-Known Member

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    Yes, I think that's right.
     
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