Has anyone watched this video by Roger Unger at Univ of Texas? I was led to it by procrastinating and reading Malcolm Kendrick's blog (which I find excellent), in particular some blogposts on rethinking diabetes here. Unger is presenting research that seems to demonstrate that the centre of Type 1 is not the body's loss of insulin, but its loss of control over glucagon. ie, that while current principles of control by insulin are not wrong, current thinking about how Type 1 works is wrong. Enjoy.