Sorry, I'm late to answer this - haven't logged in for a while.
I am on Lixisenatide and have been for about a year, and haven't had any major problems with it (other than initial nausea). Lixisenatide is not an insulin, it's a GLP1 mimetic... basically, it mimicks the actions of a hormone that our bodies create naturally when we eat food. It makes the pancreas produce more insulin, reduces the sugar that our liver stores, and reduces the rate that food passes through our stomachs and intestines. All of this means that our blood sugar stays a bit more stable.
When I was put on Lixisenatide, I was told that they put you on it for an initial 6 months, and if during 6 months either your weight reduces or your hba1c (blood sugar) reduces, then they will keep you on it. If neither of these things happen, then they will try another route.
Long term, I'm not sure whether we stay on it for good, whether it wears out it's welcome... I don't know.
But for me personally, it does seem to work.