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New study published in the BMJ on 1 October, summarised here:
No surprise really, except that for LADAs who like me are still in honeymoon stage, NPH works nicely as a single low dose of basal insulin overnight.
In the new review, researchers led by Dr. Andrea Tricco of St. Michael's Hospital in Toronto analyzed data from 39 studies. The studies compared once- and twice-daily doses of the long-acting and intermediate-acting insulin and concluded that the long-acting version was safer and more effective.
"In patients with type 1 diabetes, we found that long-acting insulin is superior to intermediate-acting insulin when it came to controlling blood sugar, preventing weight gain and treating severe hypoglycemia," Tricco said in a hospital news release.
Compared to intermediate-acting insulin, long-acting insulin significantly improved hemoglobin A1C levels, a standard blood test measure of blood sugar control.
"Those taking intermediate-acting insulin were more likely to gain weight," said Tricco, who is assistant professor in the University of Toronto's School of Public Health. "They gained an average of four to six pounds more than the participants who took most long-acting insulin doses."
The researchers also found that people with type 1 diabetes who took long-acting insulin were 38 percent less likely to develop extremely low blood sugar (severe hypoglycemia) than those who took intermediate-acting insulin.
More details here. The insulins compared were Lantus and Levemir, with NPH. "In patients with type 1 diabetes, we found that long-acting insulin is superior to intermediate-acting insulin when it came to controlling blood sugar, preventing weight gain and treating severe hypoglycemia," Tricco said in a hospital news release.
Compared to intermediate-acting insulin, long-acting insulin significantly improved hemoglobin A1C levels, a standard blood test measure of blood sugar control.
"Those taking intermediate-acting insulin were more likely to gain weight," said Tricco, who is assistant professor in the University of Toronto's School of Public Health. "They gained an average of four to six pounds more than the participants who took most long-acting insulin doses."
The researchers also found that people with type 1 diabetes who took long-acting insulin were 38 percent less likely to develop extremely low blood sugar (severe hypoglycemia) than those who took intermediate-acting insulin.
No surprise really, except that for LADAs who like me are still in honeymoon stage, NPH works nicely as a single low dose of basal insulin overnight.
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