Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic.

kokhongw · Oct 28, 2018

Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145154/

A patient diagnosed with type-II diabetes at the age of 41 who progressed through a typical series of treatment stages began showing signs of disease reversal over a decade later. Improvements of the c-peptide indicate a functional improvement of pancreatic β-islet cells around the time of an increase in strenuous exercise, the initiation of oral probiotics and GABA supplementation, and the initiation of a strict carbohydrate cycling diet. A review of the medical literature indicates that these findings have been seen in several mouse studies but limited information has been reported in human studies. The findings presented in this case report strongly suggest that these treatment techniques should be investigated further. Significant improvements in a disease commonly seen in the population would improve the lives of many patients and greatly reduce the financial burdens imposed by this disease on society.

DavidGrahamJones · Oct 28, 2018

Interesting, thanks for posting that, I need to read it a few more times to understand it more.
The one thing I noticed straight away was that his c-peptide test was determined to be 3.1, I also note that this changed (lower) in later years although they mention the tests were done after long hikes which may have had an effect.. The reference range of C-peptide is 0.8-3.1 ng/mL, so his result sounds pretty good, so long as I'm reading it right. I've had 3 c-pep tests and each came out at 1.75, so in the normal range.
Looks like I might have to get the hiking boots out, and as soon as I can work out how to take the brakes off on the exercise bike, that will be part of my regime as well.

kokhongw · Oct 28, 2018

It is actually difficult to determine if it is due to beta cells regeneration or improvement in insulin sensitivity.

But either way this case study correlates to what many of us have experienced here...near normal HbA1c and staying medication free...

I believe they draw the conclusion from the improved one off C-peptide reading " A c-peptide test was repeated showing an increase from 0.92 (age 52.2) to 3.63 (age of 55.2) as shown in Figure 3. This suggests a significant functional improvement of the β-islet cells. No case reports with such significant improvements in the c-peptide in humans have been found in the literature. The figure shows that the latest c-peptide is actually higher than the first c-peptide of 3.1 measured at the time of initial diagnosis of diabetes. "

bulkbiker · Oct 28, 2018

So from the report we get...

"a type-II diabetic patient significantly improved his dysfunctional β-islet cells using a combination of a strenuous exercise program, cyclical ketogenic diet, and oral GABA/probiotic supplementation."

Three therapies

which then gets translated to

"This case discusses the effect of strenuous exercise in improving the glycemic control of a type-II diabetic."

eh?

Diet gets a brief mention... are these guys exercise scientists or something?

kitedoc · Oct 28, 2018

And weight loss is reported over time and like diet does to rate a mention in the summary !?

NicoleC1971 · Oct 28, 2018

As his tests reveal he was producing insulin but not enough to control his bgs. 3 interventions so it is hard to determine which was the main causal factor in the reversal but the fact that he required no exogenous insulin or insulin stimulant suggests that he became more insulin sensitive (weight training and walking up hills) as well as making more of his own insulin. Ketosis seems to have been achieved via long hikes presumably without snacking His his recorded intake of carbs is moderate (100g most days with slightly more at the weekend) Not sure what a ramping diet is! As BulkB iker says the interpretation seems to have some bias attached given the fact that as well as intense exercise he had also significantly reduced his carb intake.
low carbohydrate ramping diet used by many weight lifters was adopted at age 53 years. Figure 5 illustrates the number of carbohydrates sorted by day of week over a two-year average between the ages of 53 and 55 years. On Saturday an average of a 19.3 km hike was made driving the patient into a post exercise ketogenic state lasting into Wednesday or Thursday as confirmed by urine acetoacetic acid ketone test strips. Ketosis was identified by the presence of urine ketones ≥ 5 mg/dl in the absence of urine glucose.

kitedoc · Oct 28, 2018

Mm. "..driving the patient into a post exercise ketogenic state ... " does this mean he was being encouraged, goaded into this state? That seems to happen on shows like "the Biggest Loser" and you wonder why so many fail later (apart from perhaps the wrong dietary advice)?? And who is going to be fit enough, time enough or well enough to be doing 15 km plus hikes ??

bulkbiker · Oct 28, 2018

NicoleC1971 said:
post exercise ketogenic state

So one has to wonder if ketosis was the aim (and why measure it if it wasn't) why not just follow a keto way of eating. Sometimes it seems these researchers are blinded by their own (alleged) cleverness..

NicoleC1971 · Oct 28, 2018

bulkbiker said:
So one has to wonder if ketosis was the aim (and why measure it if it wasn't) why not just follow a keto way of eating. Sometimes it seems these researchers are blinded by their own (alleged) cleverness..

It doesn't seem to have been in any way scientific because of the different interventions. Perhaps more of a case study/ N of 1 that they have published for the sake of publishing something....

Guzzler · Oct 28, 2018

Please correct me if I am wrong, a few months ago I viewed a lecture by a pathologist who stated that the only way to judge beta cell status was post mortem. He also said that pm must be within one hour of death and that biopsy of the pancreas in life is impossible. As we know beta cell number/function can diminish but c peptide can be improved with remaining beta cells.
So in this n=1 study the gentleman was/is middle aged, acheived ketosis on 100g carbs per day and regained insulin sensitivity (?) Without meds and by running around the block 27 times before breakfast every week.
Forgive me but is this not just another 'Eat less Move more' study?

Note to self: Pauline, please get something done about your nasty, suspicious mind.

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