Effects of insulin and oral antidiabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects

February 7, 2011

J. Joya-Galeana et al. DOI: 10.1002/dmrr.1185

The authors set out to test potential differences between the actions of anti-diabetic medications, they examined the effects of oral hypoglycemic agents versus insulin glargine-apidra therapy in T2DM.

OHA and IT achieved adequate glycemic control and the effects on circulating and muscle inflammatory biomarkers were similar, but only OHA improved insulin sensitivity, vascular function and CIMT.

They went on to posit that the findings in a small sample suggest that the use of OHA provide additional benefits to patients with T2DM.

Article information
Diabetes/Metabolism Research and Reviews
February 7, 2011
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