Proteinuria in Diabetes: Bystander or Pathway to Cardiorenal Disease

November 29, 2010

Proteinuria in Diabetes: Bystander or Pathway to Cardiorenal Disease? Is a question that was asked by Janaka Karalliedde and Giancarlo Viberti in their paper published in the Journal of the American Society of Nephrology.

They critically reviewed available data to determine whether the association between albuminuria and cardiorenal disease is causative, and their conclusion was that for diabetic kidney disease, there is convincing epidemiologic and experimental evidence to assign clinical albuminuria status as a surrogate endpoint, but for lower levels of albuminuria (microalbuminuria and normoalbuminuria), the evidence is inconclusive or not available.

They also posit that albuminuria of any degree is unlikely to be causally related to diabetic cardiovascular disease, but its onset might be useful to identify those subjects at cardiovascular risk and to detect and treat other modifiable risk factors.

Article information
Topic:
Pathology
Author:
Source:
Journal of the American Society of Nephrology
Added:
November 29, 2010
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