Study confirms how diabetes drugs can increase heart risk

Wed, 24 Jun 2009
A recent study clearly explains how a particular diabetes drug class ups the risk of people with diabetes developing heart problems . The drug class, Thiazolidinediones, have been in the media spotlight since Avandia (rosiglitazone), a GlaxoSmithKline drug was linked with greater heart attack risk.

A team at Washington University School of Medicine in St Louis, Missouri found a particular molecule that is activated by the diabetic drugs and could cause heart failure . Clay Semenkovich, an endocrinologist, reportedly commented: "We already knew if you had heart failure you probably should not be taking these drugs, but this paper provides an additional explanation why."

The discovery was made accidentally as a team investigated what happens when tissues enlarge. The results of the diabetes study were published in the June Issue of Cell Metabolism.
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