Bone fracture recovery can be delayed by diabetes

According to recent diabetes research published in the American Journal of Pathology, a molecule present amongst people with diabetes could delay bone fracture healing. The study confirms that diabetics may experience low bone density, a condition often associated with delayed healing and higher risks of bone fracture.
The molecule TNF-a was observed in greater levels during the healing process, with researchers revealing that animals with diabetes faced a greater loss of cartilage in their bones.
One researcher was reported in diabetes news as commenting: “TNF-a dysregulation plays a prominent role in the recently identified catabolic events associated with diabetic fracture healing.” In future studies, Dr. Graves and colleagues plan to “examine the effect of FOXO1 on mineralized tissue to examine how it may regulate factors that control bone resorption and osteoclastogenesis, in addition to effects it may have on osteoblastic cells.”