I note that most of the testing was done with either 500 mcg or 3 x 200mcg, and only one mention of 1000 mcg, I am myself very suspicious of claims that something reduces insulin resistance especially in vivo. it is extremely difficult to measure this in a live subject, and normally requires analysis by mass spectrometer to detect enzymes in the blood, It cannot realisticlly be done by measuring glucose levels in the blood, which is what most of these experiments use. Even a CGM will not provide the answer. It will show glucose being reduced in the plasma, but does not show where it has gone. Didi it go into the cells, was it stored as glycogen, or was it used directly by the muscles. Or, more importantly, was it filtered out by the kidneys, and simply excreted. I have only seen a couple of experiments that had the correct instrumentation to make the declaration valid, and that was for mainline meds, not supplements or alternative therapies. Even Metformin is as yet unproven against this claim, as far as I can tell, although I believe one test has shown a very small effect in peripheral muscles. I also believe that there are many 'types' of insulin resistance that have different trigger mechanisms, but these tend to be lumped together as ' unable to properly use insulin'