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Type 1.5/LADA Diabetes
Anti GAD Antibodies - high levels
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<blockquote data-quote="phoenix" data-source="post: 616595" data-attributes="member: 12578"><p>As you probably realise, Addisons, Hashimotos and T1 are often linked together in what's called a polyendocrine syndrome. . There are similar genetic associations so obviously there is an increased risk as there is of other autoimmune diseases including T1</p><p> </p><p>. However, it isn't just as simple as genetics (if one identical twin gets T1, there is 'only' a 50% chance that his identical sibling will develop it)</p><p> </p><p> I doubt anyone can confidently quantify the risk, other than it is higher than for people without antibodies or other associated conditions. If someone has diabetes then the presence of GAD antibodies helps distinguish T1 from T2. However, GADA is linked to at least one other autoimmune condition and also people without diabetes may have these antibodies. </p><p> There are a very few trials where people have been tested for antibodies to see if they would develop diabetes in the future. One large trial, the DCCT tested the relatives of people with diabetes for several antibodies and then looked at them again 10 years later. Those that had several different types of (diabetes) antibodies had a greater risk. Those that had GAD alone had about a 20 % risk over ten years.</p><p> <a href="http://www.diapedia.org/type-1-diabetes-mellitus/autoantibody-markers" target="_blank">http://www.diapedia.org/type-1-diabetes-mellitus/autoantibody-markers</a></p><p> </p><p> Personally, I know of no evidence that changing diet will prevent the development of T1 . There will certainly be an environmental trigger but results of studies are very conflicting.</p><p> There are studies that have looked at the early introduction of cows milk or cereals (ie after weaning) but there are also studies that suggest certain viruses.to be implicated.</p><p>I would try not to worry, (hard I know, I have the T1 and the Hashimotos and Addison's is the one I worry about). You will know if your insulin production is lower when the C pep is done. If you have got a lower production then it may be still some years before diabetes develops.</p></blockquote><p></p>
[QUOTE="phoenix, post: 616595, member: 12578"] As you probably realise, Addisons, Hashimotos and T1 are often linked together in what's called a polyendocrine syndrome. . There are similar genetic associations so obviously there is an increased risk as there is of other autoimmune diseases including T1 . However, it isn't just as simple as genetics (if one identical twin gets T1, there is 'only' a 50% chance that his identical sibling will develop it) I doubt anyone can confidently quantify the risk, other than it is higher than for people without antibodies or other associated conditions. If someone has diabetes then the presence of GAD antibodies helps distinguish T1 from T2. However, GADA is linked to at least one other autoimmune condition and also people without diabetes may have these antibodies. There are a very few trials where people have been tested for antibodies to see if they would develop diabetes in the future. One large trial, the DCCT tested the relatives of people with diabetes for several antibodies and then looked at them again 10 years later. Those that had several different types of (diabetes) antibodies had a greater risk. Those that had GAD alone had about a 20 % risk over ten years. [url]http://www.diapedia.org/type-1-diabetes-mellitus/autoantibody-markers[/url] Personally, I know of no evidence that changing diet will prevent the development of T1 . There will certainly be an environmental trigger but results of studies are very conflicting. There are studies that have looked at the early introduction of cows milk or cereals (ie after weaning) but there are also studies that suggest certain viruses.to be implicated. I would try not to worry, (hard I know, I have the T1 and the Hashimotos and Addison's is the one I worry about). You will know if your insulin production is lower when the C pep is done. If you have got a lower production then it may be still some years before diabetes develops. [/QUOTE]
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