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<blockquote data-quote="Oldvatr" data-source="post: 1497796" data-attributes="member: 196898"><p>If it is the active ingredient that is the cause of the Lactic Acidosis, then it would seem that standard Metformin should not be any different than the modified release version since it is the added enteric varnish that delays the absorption.</p><p></p><p>There may be differences in filtering or purifying the active ingredient that differs between brands. but should not make it any more injurious or dangerous. Glucophage was actually the first supplier of Metformin for diabetes use, having derived it from the French Lily otherwise known in folk lore as Goats Rue, so the stomach after effects seems to be something we share with goats. Certainly the standard Release Metformin is supposed to give worse side effects, but I was on standard tabs for many years without too much trouble.</p><p></p><p>The TiO2 is purely colouring for most white tabs on the market and applies to both standard and XR . SR variants, so is unavoidable it seems. but a lifelong habit of 4 large tabs a day will amount to a veritable paintpot of the stuff, which is why I have elected to halve my dose. There are reports that TiO2 can be retained by the kidneys in humans in vivo. Theres a novelty - white kidneys! </p><p></p><p>The replacement tabs arrived this morning, but are film coated (but not delay action time bombs. so do not have the shellac). Will be interesting if my bgl stabilises or drops again after swapping the others out. I was prepared to need to adjust my diet to compensate for halving my dose, but the size of the bump has taken me by surprise.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 1497796, member: 196898"] If it is the active ingredient that is the cause of the Lactic Acidosis, then it would seem that standard Metformin should not be any different than the modified release version since it is the added enteric varnish that delays the absorption. There may be differences in filtering or purifying the active ingredient that differs between brands. but should not make it any more injurious or dangerous. Glucophage was actually the first supplier of Metformin for diabetes use, having derived it from the French Lily otherwise known in folk lore as Goats Rue, so the stomach after effects seems to be something we share with goats. Certainly the standard Release Metformin is supposed to give worse side effects, but I was on standard tabs for many years without too much trouble. The TiO2 is purely colouring for most white tabs on the market and applies to both standard and XR . SR variants, so is unavoidable it seems. but a lifelong habit of 4 large tabs a day will amount to a veritable paintpot of the stuff, which is why I have elected to halve my dose. There are reports that TiO2 can be retained by the kidneys in humans in vivo. Theres a novelty - white kidneys! The replacement tabs arrived this morning, but are film coated (but not delay action time bombs. so do not have the shellac). Will be interesting if my bgl stabilises or drops again after swapping the others out. I was prepared to need to adjust my diet to compensate for halving my dose, but the size of the bump has taken me by surprise. [/QUOTE]
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