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Metformin/Biguanides
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<blockquote data-quote="Oldvatr" data-source="post: 1498556" data-attributes="member: 196898"><p>The incidence of metformin associated lactic acidosis is quite rare, about 1 in 10k. However there is an FDA warning (revised 2016) that applies, which we still need to take note of, as follows:</p><p><a href="https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0090404/" target="_blank">https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0090404/</a></p><p></p><p>I think the XR versions tend to use shellac or chitin, but the SR ones use a plastic matrix that swells when wet, and allows slow release throught the gunk. Acrylic or similar polymer is used, hence the plasticiser I indicated earlier, Either way it is not too clear as to how safe these substances are in the long term (10 or more years) especially when taking 2 grams of tabs a day like I was.</p><p></p><p>This thread is intended to be about Sukkarto (not the Phillipines ex president) as this is what was slipped into my medi wallet without my knowledge, and I am concerned about a sudden rise in bgl since starting it. I know it may just be the dose alteration, but may also be the way I react to XR meds. Now I am using IR variant, and will see if things change for the better or worse. It is also a raspberry across the GP practice for making a change without telling me and it was not directly compatible with the med I was on. Others may suffer this subterfuge and this is a warning to check the packets when they deliver them especially if re-packaged in a medi wallet without the packaging or literature. I had to go to the pharmacist to ask what Sukkarto was, since it is not apparent that it is Metformin, or that it is modified release.</p></blockquote><p></p>
[QUOTE="Oldvatr, post: 1498556, member: 196898"] The incidence of metformin associated lactic acidosis is quite rare, about 1 in 10k. However there is an FDA warning (revised 2016) that applies, which we still need to take note of, as follows: [URL]https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0090404/[/URL] I think the XR versions tend to use shellac or chitin, but the SR ones use a plastic matrix that swells when wet, and allows slow release throught the gunk. Acrylic or similar polymer is used, hence the plasticiser I indicated earlier, Either way it is not too clear as to how safe these substances are in the long term (10 or more years) especially when taking 2 grams of tabs a day like I was. This thread is intended to be about Sukkarto (not the Phillipines ex president) as this is what was slipped into my medi wallet without my knowledge, and I am concerned about a sudden rise in bgl since starting it. I know it may just be the dose alteration, but may also be the way I react to XR meds. Now I am using IR variant, and will see if things change for the better or worse. It is also a raspberry across the GP practice for making a change without telling me and it was not directly compatible with the med I was on. Others may suffer this subterfuge and this is a warning to check the packets when they deliver them especially if re-packaged in a medi wallet without the packaging or literature. I had to go to the pharmacist to ask what Sukkarto was, since it is not apparent that it is Metformin, or that it is modified release. [/QUOTE]
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