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<blockquote data-quote="Winnie53" data-source="post: 890510" data-attributes="member: 160246"><p>Lilliepop, I did some more looking around this morning. You can too by doing a search on "burning mouth syndrome diabetes". It appears that there are multiple causes of BMS. Diabetes appears to be one cause. This article, which was written in 2002 or later, provides a good overview with links to encouraging studies done 10 or more years ago - (also other possible causes that you can investigate)...</p><p></p><p><em><strong>Is There a BMS-Diabetes Connection?</strong> </em></p><p><em>A collaboration of researchers from universities in Naples and London decided to investigate the possibility that lipoic acid (technically, alpha-lipoic acid, and also known as thioctic acid) might be good for treating BMS, because of an intriguing link that may exist between BMS and diabetes, for which lipoic acid is known to be helpful. </em></p><p><em></em></p><p><em>It had been noted long ago that many patients with BMS have high blood glucose levels, although no consistent or causal relationship has been documented.5 More recent studies of various kinds have led to the suspicion that BMS, despite its maddeningly ambiguous and seemingly numerous origins, is a kind of peripheral neuropathy, a common symptom of long-term, poorly controlled diabetes (it can also occur independently of diabetes). </em></p><p><em></em></p><p><em>In medicine, peripheral means far from the center of the body, which usually means the extremities, but in this case it means the mouth (far enough). Neuropathy means nerve damage, and there are different causes, including high glucose levels, although how glucose damages nerves is not clear. Neuropathy generally manifests either as severe pain or as a loss of feeling - an all-or-nothing deal. </em></p><p><em></em></p><p><em><strong>Lipoic Acid Works Well on BMS</strong> </em></p><p><em>So what we have is an apparent peripheral neuropathy with a possible connection to diabetes - and it's known that lipoic acid is effective in treating neuronal (nerve-cell) damage, especially in diabetic neuropathy.6-8 You connect the dots. The Italian-British research team certainly did, and the initial result was a randomized, placebo-controlled - but open (not blinded) - clinical trial of the efficacy of lipoic acid on the one symptom of burning mouth syndrome: pain.9 The study involved 42 patients (two age- and sex-matched groups of 21 each), all with classic cases of BMS and no other conditions that might confound the results. </em></p><p><em></em></p><p><em>The results were highly positive: 76% of the test subjects taking lipoic acid (600 mg/day for 20 days, followed by 200 mg/day for 10 days) showed some improvement, with 43% showing "decided" improvement. By contrast, only 14% of the control subjects taking placebo showed some improvement (0% had decided improvement). When the controls were then switched over to lipoic acid for 30 days, their improvement rate increased to 67% (52% had decided improvement). No side effects were reported, which is consistent with lipoic acid's excellent reputation for safety. </em></p><p><em></em></p><p><em><strong>Lipoic Acid Works Really Well on BMS</strong> </em></p><p><em>Encouraged by these results - which bolstered their belief that BMS may be a form of peripheral neuropathy - the same research team undertook a more rigorous study (randomized, placebo-controlled, and double-blind) with the same objective.10 This time, 60 patients were involved (two groups of 30 each).</em></p><p><em></em></p><p><em>This time the results were even better: 97% of the subjects on lipoic acid (600 mg/day for 2 months) showed some improvement (73% had decided improvement), whereas 40% of the controls showed some improvement (0% had decided improvement). In the lipoic acid group, four patients (13%) showed "resolution," i.e., a complete cessation of pain, which amounts to a cure; this did not occur in any of the controls. None of the patients on lipoic acid got worse during the course of the study, whereas six (20%) of the controls did. Again, there were no side effects.</em></p><p></p><p>Read the entire article here... <a href="http://www.life-enhancement.com/magazine/article/726-lipoic-acid-helps-quench-the-fire-of-burning-mouth-syndrome" target="_blank">http://www.life-enhancement.com/magazine/article/726-lipoic-acid-helps-quench-the-fire-of-burning-mouth-syndrome</a></p><p></p><p>Lilliepop, neuropathy, unfortunately, is an all too common complication of diabetes. I believe more than 100 types have been described. So the alpha-lipoic acid (ALA) is a good place to start along with keeping your blood glucose levels within or as close as possible to the normal range, which you are already doing, which is good. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p><p></p><p>To that I'll add only that nutrients are often synergistic, by that I mean that sometimes taking "A" and "B" sometimes works better than taking "A" or "B" alone. So, when trying to find something that works for me, I give "A" a chance to work, then add "B". If the two together work, I then experiment with removing "A" to see if "B" alone works (so I'm taking the minimum of nutritional supplements needed). If "B" alone doesn't work, I add back the "A" again.</p><p></p><p>If the ALA doesn't work, the next question in my mind would be whether or not you have vitamin B deficiencies, because 5 of the 8 B vitamins have been found to be helpful in treating neuropathy. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p><p></p><p>Hopefully, someone else will see your post and share what worked for them. If not, you'll know in time whether or not the ALA is working. The good news is that it's good for you, whether it works for your BMS or not. Fingers and toes crossed it reduces or eliminates your BMS symptoms. <img src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" class="smilie smilie--sprite smilie--sprite1" alt=":)" title="Smile :)" loading="lazy" data-shortname=":)" /></p></blockquote><p></p>
[QUOTE="Winnie53, post: 890510, member: 160246"] Lilliepop, I did some more looking around this morning. You can too by doing a search on "burning mouth syndrome diabetes". It appears that there are multiple causes of BMS. Diabetes appears to be one cause. This article, which was written in 2002 or later, provides a good overview with links to encouraging studies done 10 or more years ago - (also other possible causes that you can investigate)... [I][B]Is There a BMS-Diabetes Connection?[/B] A collaboration of researchers from universities in Naples and London decided to investigate the possibility that lipoic acid (technically, alpha-lipoic acid, and also known as thioctic acid) might be good for treating BMS, because of an intriguing link that may exist between BMS and diabetes, for which lipoic acid is known to be helpful. It had been noted long ago that many patients with BMS have high blood glucose levels, although no consistent or causal relationship has been documented.5 More recent studies of various kinds have led to the suspicion that BMS, despite its maddeningly ambiguous and seemingly numerous origins, is a kind of peripheral neuropathy, a common symptom of long-term, poorly controlled diabetes (it can also occur independently of diabetes). In medicine, peripheral means far from the center of the body, which usually means the extremities, but in this case it means the mouth (far enough). Neuropathy means nerve damage, and there are different causes, including high glucose levels, although how glucose damages nerves is not clear. Neuropathy generally manifests either as severe pain or as a loss of feeling - an all-or-nothing deal. [B]Lipoic Acid Works Well on BMS[/B] So what we have is an apparent peripheral neuropathy with a possible connection to diabetes - and it's known that lipoic acid is effective in treating neuronal (nerve-cell) damage, especially in diabetic neuropathy.6-8 You connect the dots. The Italian-British research team certainly did, and the initial result was a randomized, placebo-controlled - but open (not blinded) - clinical trial of the efficacy of lipoic acid on the one symptom of burning mouth syndrome: pain.9 The study involved 42 patients (two age- and sex-matched groups of 21 each), all with classic cases of BMS and no other conditions that might confound the results. The results were highly positive: 76% of the test subjects taking lipoic acid (600 mg/day for 20 days, followed by 200 mg/day for 10 days) showed some improvement, with 43% showing "decided" improvement. By contrast, only 14% of the control subjects taking placebo showed some improvement (0% had decided improvement). When the controls were then switched over to lipoic acid for 30 days, their improvement rate increased to 67% (52% had decided improvement). No side effects were reported, which is consistent with lipoic acid's excellent reputation for safety. [B]Lipoic Acid Works Really Well on BMS[/B] Encouraged by these results - which bolstered their belief that BMS may be a form of peripheral neuropathy - the same research team undertook a more rigorous study (randomized, placebo-controlled, and double-blind) with the same objective.10 This time, 60 patients were involved (two groups of 30 each). This time the results were even better: 97% of the subjects on lipoic acid (600 mg/day for 2 months) showed some improvement (73% had decided improvement), whereas 40% of the controls showed some improvement (0% had decided improvement). In the lipoic acid group, four patients (13%) showed "resolution," i.e., a complete cessation of pain, which amounts to a cure; this did not occur in any of the controls. None of the patients on lipoic acid got worse during the course of the study, whereas six (20%) of the controls did. Again, there were no side effects.[/I] Read the entire article here... [URL]http://www.life-enhancement.com/magazine/article/726-lipoic-acid-helps-quench-the-fire-of-burning-mouth-syndrome[/URL] Lilliepop, neuropathy, unfortunately, is an all too common complication of diabetes. I believe more than 100 types have been described. So the alpha-lipoic acid (ALA) is a good place to start along with keeping your blood glucose levels within or as close as possible to the normal range, which you are already doing, which is good. :) To that I'll add only that nutrients are often synergistic, by that I mean that sometimes taking "A" and "B" sometimes works better than taking "A" or "B" alone. So, when trying to find something that works for me, I give "A" a chance to work, then add "B". If the two together work, I then experiment with removing "A" to see if "B" alone works (so I'm taking the minimum of nutritional supplements needed). If "B" alone doesn't work, I add back the "A" again. If the ALA doesn't work, the next question in my mind would be whether or not you have vitamin B deficiencies, because 5 of the 8 B vitamins have been found to be helpful in treating neuropathy. :) Hopefully, someone else will see your post and share what worked for them. If not, you'll know in time whether or not the ALA is working. The good news is that it's good for you, whether it works for your BMS or not. Fingers and toes crossed it reduces or eliminates your BMS symptoms. :) [/QUOTE]
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