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<blockquote data-quote="Dennis" data-source="post: 92867" data-attributes="member: 1338"><p><strong>Re: Anyone use Byetta?</strong></p><p></p><p></p><p>Hi Jude,</p><p></p><p>The way the Lilly helpdesk explained it to me was that exenatide is not a natural substance. Although it is derived from the saliva of the American gila monster, that in itself is alien to the human body. Because of this the body initially goes into reject mode and tries to get rid of this "alien" substance. Lilly reckon that it takes around 30 days to become fully acclimatised to the lower dose, and can take a similar time to acclimatise to the higher dose. The problem with this acclimatisation period is that, even if you are lucky and don't experience the nausea, if you were to move up to the higher dose too soon then it just makes the body's attempted rejection (and the nausea) more intense. </p><p></p><p>From what I have seen in myself and many others, the weight loss kicks in pretty well at the 5mcg level, but the BG lowering is quite small at that level. On 10mcg the weight loss doesn't seem to intensify (just carries on at the same rate as it was on the lower dose) but there is a much more marked reduction on BG. I don't think the acclimatisation period comes into weight or BG reduction because many report that both started within a week of starting the lower dose.</p><p></p><p>Your rising blood sugars towards lunch do sound like possibly a liver dump problem. If your BS has dropped significantly at any time of the day then the liver tries to "help out" by creating glucose. It's only when you eat something that the pancreas sends the liver a message to stop generating glucose.</p></blockquote><p></p>
[QUOTE="Dennis, post: 92867, member: 1338"] [b]Re: Anyone use Byetta?[/b] Hi Jude, The way the Lilly helpdesk explained it to me was that exenatide is not a natural substance. Although it is derived from the saliva of the American gila monster, that in itself is alien to the human body. Because of this the body initially goes into reject mode and tries to get rid of this "alien" substance. Lilly reckon that it takes around 30 days to become fully acclimatised to the lower dose, and can take a similar time to acclimatise to the higher dose. The problem with this acclimatisation period is that, even if you are lucky and don't experience the nausea, if you were to move up to the higher dose too soon then it just makes the body's attempted rejection (and the nausea) more intense. From what I have seen in myself and many others, the weight loss kicks in pretty well at the 5mcg level, but the BG lowering is quite small at that level. On 10mcg the weight loss doesn't seem to intensify (just carries on at the same rate as it was on the lower dose) but there is a much more marked reduction on BG. I don't think the acclimatisation period comes into weight or BG reduction because many report that both started within a week of starting the lower dose. Your rising blood sugars towards lunch do sound like possibly a liver dump problem. If your BS has dropped significantly at any time of the day then the liver tries to "help out" by creating glucose. It's only when you eat something that the pancreas sends the liver a message to stop generating glucose. [/QUOTE]
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