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Diabetes Discussion
Type 1.5/LADA Diabetes
C peptide test and Medication
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<blockquote data-quote="GDM06" data-source="post: 2612839" data-attributes="member: 42653"><p>100% tell you that insulin is not triggered constantly with GLP-1 agonist as in sulphonylureas. I have done a lot of literature reviews on GLP-1 agonists and my background is research.</p><p>When you take GLP-1 agonist you don't get an instant reduction in blood sugar as you do with sulphonylureas.</p><p>I am not saying GLP-1 agonist does not stimulate insulin production in the absence of food, but it's effect is more pronounced in the presence of food. The effect is different from Sulphonylureas.</p><p>You check out - Shah M, Vella A. Effects of GLP-1 on appetite and weight. Rev Endocr Metab Disord. 2014 Sep;15(3):181-7. doi: 10.1007/s11154-014-9289-5. PMID: 24811133; PMCID: PMC4119845.</p><p>The exact word here - GLP-1 enhances insulin secretion and inhibits glucagon-release in a glucose-dependent manner both in normal individuals as well as in patients with type 2 diabetes. It works in a glucose-dependent manner.</p></blockquote><p></p>
[QUOTE="GDM06, post: 2612839, member: 42653"] 100% tell you that insulin is not triggered constantly with GLP-1 agonist as in sulphonylureas. I have done a lot of literature reviews on GLP-1 agonists and my background is research. When you take GLP-1 agonist you don't get an instant reduction in blood sugar as you do with sulphonylureas. I am not saying GLP-1 agonist does not stimulate insulin production in the absence of food, but it's effect is more pronounced in the presence of food. The effect is different from Sulphonylureas. You check out - Shah M, Vella A. Effects of GLP-1 on appetite and weight. Rev Endocr Metab Disord. 2014 Sep;15(3):181-7. doi: 10.1007/s11154-014-9289-5. PMID: 24811133; PMCID: PMC4119845. The exact word here - GLP-1 enhances insulin secretion and inhibits glucagon-release in a glucose-dependent manner both in normal individuals as well as in patients with type 2 diabetes. It works in a glucose-dependent manner. [/QUOTE]
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