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Can hba1c be too low?
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<blockquote data-quote="douglas99" data-source="post: 706466" data-attributes="member: 38028"><p>It is actually a very meaningless study to be honest.</p><p>Mortality of all subjects will be 100%.</p><p>HbA1c will have no effect on the outcome, and as the figures are 'adjusted' the results are as good as the algorithm for the adjustments.</p><p>And there are a lot to get through.</p><p></p><p>quote ' Adjusted hazard ratios for the association between HbA1c and all-cause mortality among participants without diabetes using a quadratic spline with knots at the 2.5, 10, 50, 90, and 97.5 percentiles. Adjusted for age, race-ethnicity, sex, lifestyle factors (education, income, current smoking, alcohol consumption, physical activity, body mass index, and aspirin use), cardiovascular factors (systolic blood pressure, antihypertensive medication use, total cholesterol, HDL cholesterol, log triglycerides, elevated C-reactive protein, and history of CVD), metabolic factors (prior diagnosis of thyroid disease, thyroid-stimulating hormone, estimated glomerular filtration rate, and albuminuria), red blood cell indices (hemoglobin, red blood cell distribution width, mean cell volume, and serum folate), iron storage indices (serum albumin, ferritin, and transferrin saturation), and liver function indices (hepatitis C seropositivity, AST, and ALT)'</p></blockquote><p></p>
[QUOTE="douglas99, post: 706466, member: 38028"] It is actually a very meaningless study to be honest. Mortality of all subjects will be 100%. HbA1c will have no effect on the outcome, and as the figures are 'adjusted' the results are as good as the algorithm for the adjustments. And there are a lot to get through. quote ' Adjusted hazard ratios for the association between HbA1c and all-cause mortality among participants without diabetes using a quadratic spline with knots at the 2.5, 10, 50, 90, and 97.5 percentiles. Adjusted for age, race-ethnicity, sex, lifestyle factors (education, income, current smoking, alcohol consumption, physical activity, body mass index, and aspirin use), cardiovascular factors (systolic blood pressure, antihypertensive medication use, total cholesterol, HDL cholesterol, log triglycerides, elevated C-reactive protein, and history of CVD), metabolic factors (prior diagnosis of thyroid disease, thyroid-stimulating hormone, estimated glomerular filtration rate, and albuminuria), red blood cell indices (hemoglobin, red blood cell distribution width, mean cell volume, and serum folate), iron storage indices (serum albumin, ferritin, and transferrin saturation), and liver function indices (hepatitis C seropositivity, AST, and ALT)' [/QUOTE]
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