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Confused About Insulin Resistance
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<blockquote data-quote="Brunneria" data-source="post: 858895" data-attributes="member: 41816"><p>Me too.</p><p></p><p>And I'm intimately acquainted with IR.</p><p></p><p>But (as I'm sure you have already read) there are other things that increase insulin resistance as well as a fatty liver. These include subcutaneous fat, hormone conditions (eg PCOS) and some drugs. There are probably more.</p><p></p><p>Plus there is also the question of scarring.</p><p></p><p>I was surprised to read this when I came across it, but now it seems perfectly obvious... A liver isn't designed to get fat and then defat. And rather like alcoholic cirrhosis of the liver, scars can develop in the liver. These scars can inhibit normal function.</p><p></p><p>So there is no guarantee that defattifying will restore normal liver function, or that it is even possible to get beneath the personal fat threshold, because the personal fat threshold changes over time, depending on many things, including age, liver scarring, fitness level, and all those other IR generating factors.</p><p></p><p>It's a hugely complex issue, and sadly it all boils down to the individual's body and lifestyle and environment, much of which is unquantifiable. Even if a person defats and 'reverses' their T2 at 40, and keeps the weight off, there is no guarantee they won't get the symptoms of D back, years later, as their PFT shifts downwards with age.</p><p></p><p>So it's unpredictable, variable and very frustrating!</p></blockquote><p></p>
[QUOTE="Brunneria, post: 858895, member: 41816"] Me too. And I'm intimately acquainted with IR. But (as I'm sure you have already read) there are other things that increase insulin resistance as well as a fatty liver. These include subcutaneous fat, hormone conditions (eg PCOS) and some drugs. There are probably more. Plus there is also the question of scarring. I was surprised to read this when I came across it, but now it seems perfectly obvious... A liver isn't designed to get fat and then defat. And rather like alcoholic cirrhosis of the liver, scars can develop in the liver. These scars can inhibit normal function. So there is no guarantee that defattifying will restore normal liver function, or that it is even possible to get beneath the personal fat threshold, because the personal fat threshold changes over time, depending on many things, including age, liver scarring, fitness level, and all those other IR generating factors. It's a hugely complex issue, and sadly it all boils down to the individual's body and lifestyle and environment, much of which is unquantifiable. Even if a person defats and 'reverses' their T2 at 40, and keeps the weight off, there is no guarantee they won't get the symptoms of D back, years later, as their PFT shifts downwards with age. So it's unpredictable, variable and very frustrating! [/QUOTE]
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