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<blockquote data-quote="phoenix" data-source="post: 861246" data-attributes="member: 12578"><p>The fat overspill theory is a simple answer that accounts for this ; groups with certain genetics have fewer fat cells but you probably have to go beyond genetics. There are many factors that may play a part.Heres one researches ideas <a href="http://www.hindawi.com/journals/ije/2014/593982/" target="_blank">http://www.hindawi.com/journals/ije/2014/593982/</a></p><p></p><p>[ATTACH]13543[/ATTACH]</p><p></p><p>I find epigenetics to be fascinating and it's the 'hot' area of research. Genes get passed on from parents but DNA is bound up in coils and around spindles (it has to be or it wouldn't fit in the nucleus) The way it is bound up alters which genes are able to be read If a gene isn't accessible for reading then it can't be expressed . Epigenetic modifications can occur during life but these only affect individual cells (which can then be replicated but not every cell will be affected.) Much more important are epigentic changes in Utero when there are far less cells and these will then be replicated to form the trillions in the body. See the 'epigenetics mechanisms diagram on this <a href="http://en.wikipedia.org/wiki/Epigenetics" target="_blank">wiki page</a> (the article is complicated)</p><p> Children of mothers that were malnourished during the Dutch Hunger winter are believed to have suffered epigentic changes that predisposed themto type 2. Similarly, in Cambodia, where there was almost no diabetes before ,it rose 30 years after the end of the Pol Pot regime . In SE Asia as a whole , , mothers who were undernourished during pregnancy have small birth weight babies who have a greater risk of T2 in later life. Malnutrition may though not always include undernourishment , it may be that nutrient poor high calories also have epigenetic effects</p><p>Unfortunately it seems that these epigenetic changes may be passed to the next generation. (and fathers may have an influence too!)</p><p>epigenetics and diet</p><p><a href="http://learn.genetics.utah.edu/content/epigenetics/nutrition/" target="_blank">http://learn.genetics.utah.edu/content/epigenetics/nutrition/</a></p><p>also</p><p><a href="http://www.naturalhistorymag.com/features/142195/beyond-dna-epigenetics" target="_blank">http://www.naturalhistorymag.com/features/142195/beyond-dna-epigenetics</a></p></blockquote><p></p>
[QUOTE="phoenix, post: 861246, member: 12578"] The fat overspill theory is a simple answer that accounts for this ; groups with certain genetics have fewer fat cells but you probably have to go beyond genetics. There are many factors that may play a part.Heres one researches ideas [URL]http://www.hindawi.com/journals/ije/2014/593982/[/URL] [ATTACH]13543[/ATTACH] I find epigenetics to be fascinating and it's the 'hot' area of research. Genes get passed on from parents but DNA is bound up in coils and around spindles (it has to be or it wouldn't fit in the nucleus) The way it is bound up alters which genes are able to be read If a gene isn't accessible for reading then it can't be expressed . Epigenetic modifications can occur during life but these only affect individual cells (which can then be replicated but not every cell will be affected.) Much more important are epigentic changes in Utero when there are far less cells and these will then be replicated to form the trillions in the body. See the 'epigenetics mechanisms diagram on this [URL='http://en.wikipedia.org/wiki/Epigenetics']wiki page[/URL] (the article is complicated) Children of mothers that were malnourished during the Dutch Hunger winter are believed to have suffered epigentic changes that predisposed themto type 2. Similarly, in Cambodia, where there was almost no diabetes before ,it rose 30 years after the end of the Pol Pot regime . In SE Asia as a whole , , mothers who were undernourished during pregnancy have small birth weight babies who have a greater risk of T2 in later life. Malnutrition may though not always include undernourishment , it may be that nutrient poor high calories also have epigenetic effects Unfortunately it seems that these epigenetic changes may be passed to the next generation. (and fathers may have an influence too!) epigenetics and diet [URL]http://learn.genetics.utah.edu/content/epigenetics/nutrition/[/URL] also [URL]http://www.naturalhistorymag.com/features/142195/beyond-dna-epigenetics[/URL] [/QUOTE]
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