Search
Search titles only
By:
Search titles only
By:
Home
Forums
New posts
Search forums
What's new
New posts
New profile posts
Latest activity
Members
Current visitors
New profile posts
Search profile posts
Log in
Register
Search
Search titles only
By:
Search titles only
By:
New posts
Search forums
Menu
Install the app
Install
Reply to Thread
Guest, we'd love to know what you think about the forum! Take the
Diabetes Forum Survey 2024 »
Home
Forums
Diabetes Discussion
Diabetes Discussions
Have you cured or reversed type 2
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Message
<blockquote data-quote="Yorksman" data-source="post: 397908" data-attributes="member: 55568"><p>Roy Taylor, Professor of Medicine and Metabolism at Newcastle also states that the supposed inevitable progressive loss of beta cell function can be halted and the remaining cells restored to normality but, what has been totally lost is lost and so the tipping point, from non diabetic to diabetic has changed for the specific individual. Researchers are always dealing with unknowns with type 2 diabetes. What is the tipping point and why is it different for different individuals and the second unknown, what is the extent of beta cell loss and how can it be accurately estimated? From his 2008 paper:</p><p></p><p></p><p>Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause.</p><p><em>"Fatty liver causes resistance to insulin suppression of hepatic glucose output as well as raised plasma triacylglycerol. Exposure of beta cells to increased levels of fatty acids, derived from circulating and locally deposited triacylglycerol, suppresses glucose-mediated insulin secretion. This is reversible initially, but eventually becomes permanent. The essential time sequence of the pathogenesis of type 2 diabetes is now evident. Muscle insulin resistance determines the rate at which fatty liver progresses, and ectopic fat deposition in liver and islet underlies the related dynamic defects of hepatic insulin resistance and beta cell dysfunction. These defects are capable of dramatic reversal under hypoenergetic feeding conditions, completely in early diabetes and to a worthwhile extent in more established disease."</em></p><p></p><p>As individuals however, we just get told we have diabetes. No attempt is made to quantify the loss of beta cell function at the time of diagnosis.</p></blockquote><p></p>
[QUOTE="Yorksman, post: 397908, member: 55568"] Roy Taylor, Professor of Medicine and Metabolism at Newcastle also states that the supposed inevitable progressive loss of beta cell function can be halted and the remaining cells restored to normality but, what has been totally lost is lost and so the tipping point, from non diabetic to diabetic has changed for the specific individual. Researchers are always dealing with unknowns with type 2 diabetes. What is the tipping point and why is it different for different individuals and the second unknown, what is the extent of beta cell loss and how can it be accurately estimated? From his 2008 paper: Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause. [i]"Fatty liver causes resistance to insulin suppression of hepatic glucose output as well as raised plasma triacylglycerol. Exposure of beta cells to increased levels of fatty acids, derived from circulating and locally deposited triacylglycerol, suppresses glucose-mediated insulin secretion. This is reversible initially, but eventually becomes permanent. The essential time sequence of the pathogenesis of type 2 diabetes is now evident. Muscle insulin resistance determines the rate at which fatty liver progresses, and ectopic fat deposition in liver and islet underlies the related dynamic defects of hepatic insulin resistance and beta cell dysfunction. These defects are capable of dramatic reversal under hypoenergetic feeding conditions, completely in early diabetes and to a worthwhile extent in more established disease."[/i] As individuals however, we just get told we have diabetes. No attempt is made to quantify the loss of beta cell function at the time of diagnosis. [/QUOTE]
Verification
Post Reply
Home
Forums
Diabetes Discussion
Diabetes Discussions
Have you cured or reversed type 2
Top
Bottom
Find support, ask questions and share your experiences. Ad free.
Join the community »
This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies.
Accept
Learn More.…