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Type 1.5/LADA Diabetes
Help! Potential LADA, struggling to get a clear diagnosis…
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<blockquote data-quote="phoenix" data-source="post: 300637" data-attributes="member: 12578"><p><strong>Re: Help! Potential LADA, struggling to get a clear diagnosi</strong></p><p></p><p></p><p>Age isn't relevent. There may actually be more cases of T1 in adults than in children... though lots misdiagnosed.</p><p>In one study in Sweden they tested all newly diagnosed for antibodies and C peptide. Those positive for antibodies or with a low C peptide were classified as T1. There were 2 peaks , one in those aged 0-9 and the other in 50-80 year olds.Among adults 6.9% had type 1 and 93.1% type 2.Incidences of type 1 diabetes in both children and adults were very high and as high above age 50 years as in children. </p><p></p><p>There was a similar Italian study which also showed a high incidence in the early fifties (haven't time to look it up now) .</p><p></p><p>How long LADA takes to develop from the time that blood tests can show higher than normal blood glucose is something that is presumably variable. Those with higher amounts of antibodies have been shown to become insulin dependent more quickly. Most sources seem to say that it takes from a couple of years to 6 years but could be longer.</p><p></p><p>Personally I was in my early 50s when I was diagnosed with T1 (high ketones, weight loss etc). I wasn't in the UK and was sent to hospital where they did antibody and c peptide and diagnosed T1.</p><p> I am certain it was LADA, I had had what I thought was T2 for 3-4 years before that. Interestingly that started with all the classic symptoms including weight loss but which then abated for a while. During that time I ate a conventionally healthy low GI diet. </p><p> Then 3 years down the line, I very quickly lost a lot more weight, and an attempt at exercise resulted in high ketones. I think the transition to insulin dependence actually happened fairly quickly . My HbA1c was 'only' 7% so glucose hadn't been sky high in the previous 3 months yet my fasting glucose was in the mid twenties. </p><p></p><p>To the OP. A c peptide test if done in the early stages might be show insulin as low normal, not a lot of use! Someone with insulin resistance would possibly be producing high amounts of insulin. Someone who has had T2 for a long time and has lost a lot of beta cell function would have a low c peptide result as would someone who had later LADA/T1 GAD antibodies aren't definitive though they are usually present. There is a possibility of other anti bodies..</p></blockquote><p></p>
[QUOTE="phoenix, post: 300637, member: 12578"] [b]Re: Help! Potential LADA, struggling to get a clear diagnosi[/b] Age isn't relevent. There may actually be more cases of T1 in adults than in children... though lots misdiagnosed. In one study in Sweden they tested all newly diagnosed for antibodies and C peptide. Those positive for antibodies or with a low C peptide were classified as T1. There were 2 peaks , one in those aged 0-9 and the other in 50-80 year olds.Among adults 6.9% had type 1 and 93.1% type 2.Incidences of type 1 diabetes in both children and adults were very high and as high above age 50 years as in children. There was a similar Italian study which also showed a high incidence in the early fifties (haven't time to look it up now) . How long LADA takes to develop from the time that blood tests can show higher than normal blood glucose is something that is presumably variable. Those with higher amounts of antibodies have been shown to become insulin dependent more quickly. Most sources seem to say that it takes from a couple of years to 6 years but could be longer. Personally I was in my early 50s when I was diagnosed with T1 (high ketones, weight loss etc). I wasn't in the UK and was sent to hospital where they did antibody and c peptide and diagnosed T1. I am certain it was LADA, I had had what I thought was T2 for 3-4 years before that. Interestingly that started with all the classic symptoms including weight loss but which then abated for a while. During that time I ate a conventionally healthy low GI diet. Then 3 years down the line, I very quickly lost a lot more weight, and an attempt at exercise resulted in high ketones. I think the transition to insulin dependence actually happened fairly quickly . My HbA1c was 'only' 7% so glucose hadn't been sky high in the previous 3 months yet my fasting glucose was in the mid twenties. To the OP. A c peptide test if done in the early stages might be show insulin as low normal, not a lot of use! Someone with insulin resistance would possibly be producing high amounts of insulin. Someone who has had T2 for a long time and has lost a lot of beta cell function would have a low c peptide result as would someone who had later LADA/T1 GAD antibodies aren't definitive though they are usually present. There is a possibility of other anti bodies.. [/QUOTE]
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